Adipose-derived stem and progenitor cells as fillers in plastic and reconstructive surgery

被引:230
作者
Moseley, Timothy A.
Zhu, Min
Hedrick, Marc H.
机构
[1] Cytori Therapeut Inc, Div Biol, Dept Res & Technol, San Diego, CA 92121 USA
[2] Univ Calif Los Angeles, Dept Surg, Div Plast Surg, Los Angeles, CA 90024 USA
关键词
D O I
10.1097/01.prs.0000234609.74811.2e
中图分类号
R61 [外科手术学];
学科分类号
摘要
Plastic surgeons are keenly aware of the principle "replace like with like." This principle underlies much of the rationale behind the clinical use of autologous fat transplantation, despite the procedure's drawbacks. Autologous fat transplantation is frequently used for a variety of cosmetic and reconstructive indications not limited to posttraumatic defects of the face and body, involutional disorders such as hemifacial atrophy, sequelae of radiation therapy, and many aesthetic uses such as lip and facial augmentation and wrinkle therapy. However, the limitations of fat transplantation are well known, particularly the long-term unpredictability of volume maintenance. Regenerative cell-based strategies such as those encompassing the use of stem cells hold tremendous promise for augmentation of the soft-tissue space. Preclinical studies and early clinical series show that adipose-derived stem cells offer the possibility of finally fulfilling the key principle of replacing like with like as an aesthetic filler, without the drawbacks of current technology.
引用
收藏
页码:121S / 128S
页数:8
相关论文
共 58 条
[1]   Human mesenchymal stem cells modulate allogeneic immune cell responses [J].
Aggarwal, S ;
Pittenger, MF .
BLOOD, 2005, 105 (04) :1815-1822
[2]   Yield of human adipose-derived adult stem cells from liposuction aspirates [J].
Aust, L ;
Devlin, B ;
Foster, SJ ;
Halvorsen, YDC ;
Hicok, K ;
du Laney, T ;
Sen, A ;
Willingmyre, GD ;
Gimble, JM .
CYTOTHERAPY, 2004, 6 (01) :7-14
[3]   Engineered adipose tissue supplied by functional microvessels [J].
Borges, J ;
Mueller, MC ;
Padron, NT ;
Tegtmeier, F ;
Lang, EM ;
Stark, GB .
TISSUE ENGINEERING, 2003, 9 (06) :1263-1270
[4]   Allogeneic stem cell transplantation [J].
Bosi, A ;
Bartolozzi, B ;
Guidi, S .
TRANSPLANTATION PROCEEDINGS, 2005, 37 (06) :2667-2669
[5]   Mesenchymal stem cells: Cell-based reconstructive therapy in orthopedics [J].
Caplan, AI .
TISSUE ENGINEERING, 2005, 11 (7-8) :1198-1211
[6]   PERCENTAGE OF GRAFT VIABILITY VERSUS INJECTED VOLUME IN ADIPOSE AUTOTRANSPLANTS [J].
CARPANEDA, CA ;
RIBEIRO, MT .
AESTHETIC PLASTIC SURGERY, 1994, 18 (01) :17-19
[7]   Clonal multilineage differentiation of murine common pluripotent stem cells isolated from skeletal muscle and adipose stromal cells [J].
Case, J ;
Horvath, TL ;
Howell, JC ;
Yoder, MC ;
March, KL ;
Srour, EF .
HEMATOPOIETIC STEM CELLS V, 2005, 1044 :183-200
[8]  
Casteilla L, 2005, ARCH MAL COEUR VAISS, V98, P922
[9]  
Coleman SR, 2002, PLAST RECONSTR SURG, V110, P1731, DOI 10.1097/00006534-200212000-00017
[10]  
Coleman SR, 1997, CLIN PLAST SURG, V24, P347