Cerebellar dysfunction in chronic toluene abuse: Beneficial response to amantadine hydrochloride

被引：30

作者：

Deleu, D ^{[1
]}

Hanssens, Y ^{[1
]}

机构：

[1] Sultan Qaboos Univ, Coll Med, Muscat 123, Oman

来源：

JOURNAL OF TOXICOLOGY-CLINICAL TOXICOLOGY | 2000年 / 38卷 / 01期

关键词：

D O I：

10.1081/CLT-100100913

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

Case Report: A 21-year-old man who had sniffed toluene since the age of 13 presented with a 4-year history of progressive cerebellar dysfunction and visual deterioration. The patient's condition did not improve despite 5 months of abstinence. Magnetic resonance imaging revealed cerebral atrophy and hypointensity signals in the white matter and bilaterally in the globus pallidus, thalamus, red nucleus, and substantia nigra. Amantadine hydrochloride therapy (100 mg/d, then 200 mg/d) resulted in dramatic improvement of his cerebellar and visual symptoms.

引用

页码：37 / 41

页数：5

共 21 条

[1] BIOCHEMICAL-CHANGES IN DIFFERENT BRAIN-AREAS AFTER TOLUENE INHALATION [J].