Antifungal activity of thymol against clinical isolates of fluconazole-sensitive and -resistant Candida albicans

被引：73

作者：

Guo, Na ^{[1
,2
]}

Liu, Jingbo ^{[2
]}

Wu, Xiuping ^{[1
]}

Bi, Xingming ^{[1
]}

Meng, Rizeng ^{[3
]}

Wang, Xuelin ^{[1
]}

Xiang, Hua ^{[1
]}

Deng, Xuming ^{[1
]}

Yu, Lu ^{[1
]}

机构：

[1] Jilin Univ, Coll Anim Sci & Vet Med, Inst Zoonosis, Key Lab Zoonosis,Minist Educ, Changchun 130062, Peoples R China

[2] Jilin Univ, Lab Nutr & Funct Food, Changchun 130062, Peoples R China

[3] Jilin Entry Exit Inspect & Quarantine Bur, Changchun 130062, Peoples R China

来源：

JOURNAL OF MEDICAL MICROBIOLOGY | 2009年 / 58卷 / 08期

基金：

中国国家自然科学基金;

关键词：

IN-VITRO; ESSENTIAL OILS; COMBINATIONS; SYNERGISM; AZOLES;

D O I：

10.1099/jmm.0.008052-0

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Thymol (THY) was found to have in vitro antifungal activity against 24 fluconazole (FLC)-resistant and 12 FLC-susceptible clinical isolates of Candida albicans, standard strain ATCC 10231 and one experimentally induced FLC-resistant C. albicans S-1. In addition, synergism was observed for clinical isolates of C. albicans with combinations of THY-FLC and THY-amphotericin B (AMB) evaluated by the chequerboard microdilution method. The interaction intensity was determined by spectrophotometry for the chequerboard assay, and the nature of the interactions was assessed using two non-parametric approaches [fractional inhibitory concentration index (FICI) and Delta E models]. The interaction between THY-FLC or THY-AMB in FLC-resistant and -susceptible strains of C. albicans showed a high percentage of synergism by the FICI method and the Delta E method. The Delta E model gave results consistent with FICI, and no antagonistic action was observed in the strains tested.

引用

页码：1074 / 1079

页数：6

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