Persistent oxidative stress in colorectal carcinoma patients

被引：91

作者：

Gackowski, D

Banaszkiewicz, Z

Rozalski, R

Jawien, A

Olinski, R

机构：

[1] Ludwik Rydygier Med Univ Bydgoszcz, Dept Clin Biochem, PL-85092 Bydgoszcz, Poland

[2] Ludwik Rydygier Med Univ Bydgoszcz, Dept & Clin Surg, Bydgoszcz, Poland

来源：

INTERNATIONAL JOURNAL OF CANCER | 2002年 / 101卷 / 04期

关键词：

colon cancer; antioxidants; 8-oxodGuo; oxidative stress;

D O I：

10.1002/ijc.10610

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We examine whether the level of 8-oxo-2'-deoxyguanosine (8-oxodGuo) in lymphocytes DNA is higher in colon cancer when compared to the control group. Factors that may influence oxidative stress such as antioxidant vitamins and uric acid were also determined. Blood samples were obtained from a control group of 55 healthy persons and 43 colon cancers. 8-OxodGuo level and the vitamins concentration were measured by high-performance liquid chromatography. The levels of 8-oxodGuo were significantly higher whereas the concentrations of the vitamins and uric acid were significantly lower in colon cancer patients than in control group. Therefore, the decreased concentration of antioxidant vitamins together with lower amount of uric acid may be responsible for the formation of pro-oxidative environment in blood of colorectal carcinoma patients. (C) 2002 Wiley-Liss, Inc.

引用

页码：395 / 397

页数：3

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