共 41 条
The pre-B cell receptor and its role in proliferation and Ig heavy chain allelic exclusion
被引:48
作者:
Mårtensson, IL
[1
]
Rolink, A
Melchers, F
Mundt, C
Licence, S
Shimizu, T
机构:
[1] Babraham Inst, Cambridge CB2 4AT, England
[2] Sci Univ Tokyo, Chiba 2780022, Japan
基金:
英国生物技术与生命科学研究理事会;
关键词:
pre-BCR;
surrogate light chain;
VpreB and lambda 5;
IgH chain;
proliferation;
allelic exclusion;
D O I:
10.1016/S1044-5323(02)00066-0
中图分类号:
R392 [医学免疫学];
Q939.91 [免疫学];
学科分类号:
100102 ;
摘要:
The pre-B cell receptor (pre-BCR) is composed of the immunoglobulin (Ig) heavy (muH) chain and the surrogate light chain encoded by VpreB and lambda5. The pre-BCR has been implicated in precursor B cell proliferation, differentiation and IgH chain allelic exclusion. B cell development in mice lacking the transmembrane form of muH chain is blocked at the precursor B cell stage: the cells cannot proliferate or differentiate further and the IgH locus is allelically included. In mice lacking; 5, the precursor B cells, although unable to Proliferate, can nonetheless differentiate, whereas the IgH locus is allelically excluded. It was, therefore, Postulated that muH chain together with VpreB could form a pre-BCR-like receptor that would allow IgH allelic exclusion but not proliferation. In mice lacking both VpreB genes, precursor B cells do not proliferate but are able to differentiate. Surprisingly, the IgH locus is allelically excluded. This suggests that muH chains find other partner proteins to signal allelic exclusion.
引用
收藏
页码:335 / 342
页数:8
相关论文