The pre-B cell receptor and its role in proliferation and Ig heavy chain allelic exclusion

被引:48
作者
Mårtensson, IL [1 ]
Rolink, A
Melchers, F
Mundt, C
Licence, S
Shimizu, T
机构
[1] Babraham Inst, Cambridge CB2 4AT, England
[2] Sci Univ Tokyo, Chiba 2780022, Japan
基金
英国生物技术与生命科学研究理事会;
关键词
pre-BCR; surrogate light chain; VpreB and lambda 5; IgH chain; proliferation; allelic exclusion;
D O I
10.1016/S1044-5323(02)00066-0
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The pre-B cell receptor (pre-BCR) is composed of the immunoglobulin (Ig) heavy (muH) chain and the surrogate light chain encoded by VpreB and lambda5. The pre-BCR has been implicated in precursor B cell proliferation, differentiation and IgH chain allelic exclusion. B cell development in mice lacking the transmembrane form of muH chain is blocked at the precursor B cell stage: the cells cannot proliferate or differentiate further and the IgH locus is allelically included. In mice lacking; 5, the precursor B cells, although unable to Proliferate, can nonetheless differentiate, whereas the IgH locus is allelically excluded. It was, therefore, Postulated that muH chain together with VpreB could form a pre-BCR-like receptor that would allow IgH allelic exclusion but not proliferation. In mice lacking both VpreB genes, precursor B cells do not proliferate but are able to differentiate. Surprisingly, the IgH locus is allelically excluded. This suggests that muH chains find other partner proteins to signal allelic exclusion.
引用
收藏
页码:335 / 342
页数:8
相关论文
共 41 条
[1]   Fetal liver organ cultures allow the proliferative expansion of pre-B receptor-expressing pre-B-II cells and the differentiation of immature and mature B cells in vitro [J].
Ceredig, R ;
ten Boekel, E ;
Rolink, A ;
Melchers, F ;
Andersson, J .
INTERNATIONAL IMMUNOLOGY, 1998, 10 (01) :49-59
[2]   The murine VpreB1 and VpreB2 genes both encode a protein of the surrogate light chain and are co-expressed during B cell development [J].
Dul, JL ;
Argon, Y ;
Winkler, T ;
tenBoekel, E ;
Melchers, F ;
Martensson, IL .
EUROPEAN JOURNAL OF IMMUNOLOGY, 1996, 26 (04) :906-913
[3]   IMMUNOGLOBULIN HEAVY AND LIGHT CHAIN GENES REARRANGE INDEPENDENTLY AT EARLY STAGES OF B-CELL DEVELOPMENT [J].
EHLICH, A ;
SCHAAL, S ;
GU, H ;
KITAMURA, D ;
MULLER, W ;
RAJEWSKY, K .
CELL, 1993, 72 (05) :695-704
[4]   DOWN-REGULATION OF RAG1 AND RAG2 GENE-EXPRESSION IN PREB CELLS AFTER FUNCTIONAL IMMUNOGLOBULIN HEAVY-CHAIN REARRANGEMENT [J].
GRAWUNDER, U ;
LEU, TMJ ;
SCHATZ, DG ;
WERNER, A ;
ROLINK, AG ;
MELCHERS, F ;
WINKLER, TH .
IMMUNITY, 1995, 3 (05) :601-608
[5]   B cell development pathways [J].
Hardy, RR ;
Hayakawa, K .
ANNUAL REVIEW OF IMMUNOLOGY, 2001, 19 :595-621
[7]   Induction of pre-B cell proliferation after de novo synthesis of the pre-B cell receptor [J].
Hess, J ;
Werner, A ;
Wirth, T ;
Melchers, F ;
Jäck, HM ;
Winkler, TH .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (04) :1745-1750
[8]   A COMPLEX OF GLYCOPROTEINS IS ASSOCIATED WITH V(PREB)/LAMBDA(5) SURROGATE LIGHT-CHAIN ON THE SURFACE OF MU HEAVY CHAIN-NEGATIVE EARLY PRECURSOR B-CELL LINES [J].
KARASUYAMA, H ;
ROLINK, A ;
MELCHERS, F .
JOURNAL OF EXPERIMENTAL MEDICINE, 1993, 178 (02) :469-478
[9]   THE EXPRESSION OF V-PRE-B/LAMBDA-5 SURROGATE LIGHT-CHAIN IN EARLY BONE-MARROW PRECURSOR B-CELLS OF NORMAL AND B-CELL-DEFICIENT MUTANT MICE [J].
KARASUYAMA, H ;
ROLINK, A ;
SHINKAI, Y ;
YOUNG, F ;
ALT, FW ;
MELCHERS, F .
CELL, 1994, 77 (01) :133-143
[10]   TARGETED DISRUPTION OF MU-CHAIN MEMBRANE EXON CAUSES LOSS OF HEAVY-CHAIN ALLELIC EXCLUSION [J].
KITAMURA, D ;
RAJEWSKY, K .
NATURE, 1992, 356 (6365) :154-156