Protective Efficacy of a Single Immunization of a Chimeric Adenovirus Vector-Based Vaccine against Simian Immunodeficiency Virus Challenge in Rhesus Monkeys

被引：27

作者：

Barouch, Dan H. ^{[1
,7
]}

Liu, Jinyan ^{[1
]}

Lynch, Diana M. ^{[1
]}

O'Brien, Kara L. ^{[1
]}

La Porte, Annalena ^{[1
]}

Simmons, Nathaniel L. ^{[1
]}

Riggs, Ambryice M. ^{[1
]}

Clark, Sarah ^{[1
]}

Abbink, Peter ^{[1
]}

Montefiori, David C. ^{[2
]}

Landucci, Gary ^{[3
]}

Forthal, Donald N. ^{[3
]}

Self, Steven G. ^{[4
]}

Carville, Angela ^{[5
]}

Mansfield, Keith ^{[5
]}

Goudsmit, Jaap ^{[6
]}

机构：

[1] Beth Israel Deaconess Med Ctr, Div Vaccine Res, Boston, MA 02215 USA

[2] Duke Univ, Med Ctr, Durham, NC 27710 USA

[3] Univ Calif Irvine, Irvine Sch Med, Irvine, CA 92697 USA

[4] Univ Washington, Dept Biostat, Seattle, WA 98109 USA

[5] New England Primate Res Ctr, Southborough, MA 01772 USA

[6] Crucell Holland BV, NL-2301 CA Leiden, Netherlands

[7] MIT & Harvard, Ragon Inst MGH, Boston, MA 02214 USA

来源：

JOURNAL OF VIROLOGY | 2009年 / 83卷 / 18期

基金：

美国国家卫生研究院;

关键词：

HUMORAL IMMUNE-RESPONSES; PLASMID DNA VACCINE; T-CELL RESPONSE; REPLICATION; MEMORY; AIDS; IMMUNOGENICITY; RECRUITMENT; PROGRESSION; INFECTION;

D O I：

10.1128/JVI.00821-09

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Rare serotype and chimeric recombinant adenovirus (rAd) vectors that evade anti-Ad5 immunity are currently being evaluated as potential vaccine vectors for human immunodeficiency virus type 1 and other pathogens. We have recently reported that a heterologous rAd prime-boost regimen expressing simian immunodeficiency virus (SIV) Gag afforded durable partial immune control of an SIV challenge in rhesus monkeys. However, single-shot immunization may ultimately be preferable for global vaccine delivery. We therefore evaluated the immunogenicity and protective efficacy of a single immunization of chimeric rAd5 hexon hypervariable region 48 (rAd5HVR48) vectors expressing SIV Gag, Pol, Nef, and Env against a homologous SIV challenge in rhesus monkeys. Inclusion of Env resulted in improved control of peak and set point SIV RNA levels following challenge. In contrast, DNA vaccine priming did not further improve the protective efficacy of rAd5HVR48 vectors in this system.

引用

页码：9584 / 9590

页数：7

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