Review: in vitro microvessel models

被引：120

作者：

Bogorad, Max I. ^{[1
]}

DeStefano, Jackson ^{[1
]}

Karlsson, Johan ^{[1
]}

Wong, Andrew D. ^{[1
]}

Gerecht, Sharon ^{[3
]}

Searson, Peter C. ^{[1
,2
]}

机构：

[1] Johns Hopkins Univ, Inst Nanobiotechnol INBT, Baltimore, MD 21218 USA

[2] Johns Hopkins Univ, Dept Mat Sci & Engn, Baltimore, MD 21218 USA

[3] Johns Hopkins Univ, Dept Chem & Biomol Engn, Baltimore, MD 21218 USA

来源：

LAB ON A CHIP | 2015年 / 15卷 / 22期

关键词：

BLOOD-BRAIN-BARRIER; TEMPERATURE-DEPENDENT MICELLIZATION; CELLS RESIST ELONGATION; ENDOTHELIAL-CELLS; VASCULAR-PERMEABILITY; PHENOTYPIC HETEROGENEITY; ELECTRICAL-RESISTANCE; CEREBRAL MICROVESSELS; SOLUTE PERMEABILITY; CYCLIC-AMP;

D O I：

10.1039/c5lc00832h

中图分类号：

Q5 [生物化学];

学科分类号：

070307 [化学生物学];

摘要：

A wide range of perfusable microvessel models have been developed, exploiting advances in microfabrication, microfluidics, biomaterials, stem cell technology, and tissue engineering. These models vary in complexity and physiological relevance, but provide a diverse tool kit for the study of vascular phenomena and methods to vascularize artificial organs. Here we review the state-of-the-art in perfusable microvessel models, summarizing the different fabrication methods and highlighting advantages and limitations.

引用

页码：4242 / 4255

页数：14

共 123 条

[1]

Functional Vascular Endothelium Derived from Human Induced Pluripotent Stem Cells [J].

Adams, William J. ;

Zhang, Yuzhi ;

Cloutier, Jennifer ;

Kuchimanchi, Pranati ;

Newton, Gail ;

Sehrawat, Seema ;

Aird, William C. ;

Mayadas, Tanya N. ;

Luscinskas, Francis W. ;

Garcia-Cardena, Guillermo .

STEM CELL REPORTS, 2013, 1 (02) :105-113

[2]

Adamson R. H., 1994, Microcirculation (New York), V1, P251, DOI 10.3109/10739689409146752

[3]

Phenotypic heterogeneity of the endothelium I. Structure, function, and mechanisms [J].

Aird, William C. .

CIRCULATION RESEARCH, 2007, 100 (02) :158-173

[4]

Phenotypic heterogeneity of the endothelium II. Representative vascular beds [J].

Aird, William C. .

CIRCULATION RESEARCH, 2007, 100 (02) :174-190

[5]

Geometric control of vascular networks to enhance engineered tissue integration and function [J].

Baranski, Jan D. ;

Chaturvedi, Ritika R. ;

Stevens, Kelly R. ;

Eyckmans, Jeroen ;

Carvalho, Brian ;

Solorzano, Ricardo D. ;

Yang, Michael T. ;

Miller, Jordan S. ;

Bhatia, Sangeeta N. ;

Chen, Christopher S. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2013, 110 (19) :7586-7591

[6]

A microfluidic 3D in vitro model for specificity of breast cancer metastasis to bone [J].

Bersini, Simone ;

Jeon, Jessie S. ;

Dubini, Gabriele ;

Arrigoni, Chiara ;

Chung, Seok ;

Charest, Joseph L. ;

Moretti, Matteo ;

Kamm, Roger D. .

BIOMATERIALS, 2014, 35 (08) :2454-2461

[7]

Hydrogel bioprinted microchannel networks for vascularization of tissue engineering constructs [J].

Bertassoni, Luiz E. ;

Cecconi, Martina ;

Manoharan, Vijayan ;

Nikkhah, Mehdi ;

Hjortnaes, Jesper ;

Cristino, Ana Luiza ;

Barabaschi, Giada ;

Demarchi, Danilo ;

Dokmeci, Mehmet R. ;

Yang, Yunzhi ;

Khademhosseini, Ali .

LAB ON A CHIP, 2014, 14 (13) :2202-2211

[8]

A study of the temperature-dependent micellization of pluronic F127 [J].

Bohorquez, M ;

Koch, C ;

Trygstad, T ;

Pandit, N .

JOURNAL OF COLLOID AND INTERFACE SCIENCE, 1999, 216 (01) :34-40

[9]

Boland Thomas, 2006, Biotechnology Journal, V1, P910, DOI 10.1002/biot.200600081

[10]

Characterization of a microfluidic in vitro model of the blood-brain barrier (μBBB) [J].

Booth, Ross ;

Kim, Hanseup .

LAB ON A CHIP, 2012, 12 (10) :1784-1792

← 1 2 3 4 5 6 7 8 9 10 →