Senescent cells and osteoarthritis: a painful connection

被引：328

作者：

Jeon, Ok Hee ^{[1
,2
,3
]}

David, Nathaniel ^{[4
]}

Campisi, Judith ^{[3
]}

Elisseeff, Jennifer H. ^{[1
,2
]}

机构：

[1] Johns Hopkins Univ, Wilmer Eye Inst, Translat Tissue Engn Ctr, Smith Bldg,Room 5035,400 Broadway, Baltimore, MD 21231 USA

[2] Johns Hopkins Univ, Dept Biomed Engn, Smith Bldg,Room 5035,400 Broadway, Baltimore, MD 21231 USA

[3] Buck Inst Res Aging, Novato, CA USA

[4] Unity Biotechnol, Brisbane, CA USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2018年 / 128卷 / 04期

关键词：

ANTERIOR CRUCIATE LIGAMENT; SYNOVIAL LINING MACROPHAGES; SUBCHONDRAL BONE CHANGES; CELLULAR SENESCENCE; ARTICULAR-CARTILAGE; CHONDROCYTE SENESCENCE; POSTTRAUMATIC OSTEOARTHRITIS; MITOCHONDRIAL DYSFUNCTION; GENE-EXPRESSION; DNA-DAMAGE;

D O I：

10.1172/JCI95147

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

100103 [病原生物学]; 100218 [急诊医学];

摘要：

Senescent cells (SnCs) are associated with age-related pathologies. Osteoarthritis is a chronic disease characterized by pain, loss of cartilage, and joint inflammation, and its incidence increases with age. For years, the presence of SnCs in cartilage isolated from patients undergoing total knee artificial implants has been noted, but these cells' relevance to disease was unclear. In this Review, we summarize current knowledge of SnCs in the multiple tissues that constitute the articular joint. New evidence for the causative role of SnCs in the development of posttraumatic and age-related arthritis is reviewed along with the therapeutic benefit of SnC clearance. As part of their senescence-associated secretory phenotype, SnCs secrete cytokines that impact the immune system and its response to joint tissue trauma. We present concepts of the immune response to tissue trauma as well as the interactions with SnCs and the local tissue environment. Finally, we discuss therapeutic implications of targeting SnCs in treating osteoarthritis.

引用

页码：1229 / 1237

页数：9

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