The expanding family of MyD88-like adaptors in Toll-like receptor signal transduction

被引：131

作者：

McGettrick, AF ^{[1
]}

O'Neill, LAJ ^{[1
]}

机构：

[1] Univ Dublin Trinity Coll, Dept Biochem, Dublin 2, Ireland

来源：

MOLECULAR IMMUNOLOGY | 2004年 / 41卷 / 6-7期

关键词：

host defense; signal transduction; toll-like receptors; MyD88; Mal; Trif; TRAM; SARM;

D O I：

10.1016/j.molimm.2004.04.006

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Toll-like receptors (TLRs) play an essential role in the detection and elimination of invading microbes. They are type-1 transmembrane receptors, containing extracellular leucine rich repeats and an intracellular Toll/interleukin-1 receptor (TIR) domain. Upon stimulation, these receptors interact with specific TIR domain-containing adaptor proteins. Five such adaptors have been discovered to date, MyD88, Mal (MyD88 adaptor-like)/TIRAP (TIR domain-containing adaptor protein), Trif (TIR-domain-containing adaptor inducing interferon-beta), TRAM (Trif-related adaptor molecule) and SARM (SAM and ARM-containing protein). Different TLRs use different combinations of these adaptors, leading to the activation of common and unique pathways involved in the elimination of the invading microbe. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：577 / 582

页数：6

共 41 条

[1] Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function [J].

Adachi, O ;

Kawai, T ;

Takeda, K ;

Matsumoto, M ;

Tsutsui, H ;

Sakagami, M ;

Nakanishi, K ;

Akira, S .

IMMUNITY, 1998, 9 (01) :143-150

[2] Toll-like receptors: critical proteins linking innate and acquired immunity [J].

Akira, S ;

Takeda, K ;

Kaisho, T .

NATURE IMMUNOLOGY, 2001, 2 (08) :675-680

[3] Toll-like receptors: lessons from knockout mice [J].

Akira, S .

BIOCHEMICAL SOCIETY TRANSACTIONS, 2000, 28 :551-556

[4] Up-regulation of TLR9 gene expression by LPS in mouse macrophages via activation of NF-κB, ERK and p38 MAPK signal pathways [J].

An, HZ ;

Xu, HM ;

Yu, YZ ;

Zhang, MH ;

Qi, RZ ;

Yan, XY ;

Liu, SX ;

Wang, WY ;

Guo, ZH ;

Qin, ZH ;

Cao, XT .

IMMUNOLOGY LETTERS, 2002, 81 (03) :165-169

[5]

ANDREAKOS E, 2003, BLOOD, V4, P1356

[6] TIRP, a novel Toll/interleukin-1 receptor (TIR) domain-containing adapter protein involved in TIR signaling [J].

Bin, LH ;

Xu, LG ;

Shu, HB .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (27) :24526-24532

[7] IRF3 mediates a TLR3/TLR4-specific antiviral gene program [J].

Doyle, SE ;

Vaidya, SA ;

O'Connell, R ;

Dadgostar, H ;

Dempsey, PW ;

Wu, TT ;

Rao, G ;

Sun, R ;

Haberland, ME ;

Modlin, RL ;

Cheng, G .

IMMUNITY, 2002, 17 (03) :251-263

[8] Structural complementarity of Toll/interleukin-1 receptor domains in toll-like receptors and the adaptors Mal and MyD88 [J].

Dunne, A ;

Ejdebäck, M ;

Ludidi, PL ;

O'Neill, LAJ ;

Gay, NJ .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (42) :41443-41451

[9]

DUNNE A, 2003, SCI STKE, V3, P171

[10] IKKε and TBK1 are essential components of the IRF3 signaling pathway [J].

Fitzgerald, KA ;

McWhirter, SM ;

Faia, KL ;

Rowe, DC ;

Latz, E ;

Golenbock, DT ;

Coyle, AJ ;

Liao, SM ;

Maniatis, T .

NATURE IMMUNOLOGY, 2003, 4 (05) :491-496

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