Characterization, chromosomal localization, and the complete 30-kb DNA sequence of the human Jagged2 (JAG2) gene

被引：15

作者：

Deng, Y

Madan, A

Banta, AB

Friedman, C

Trask, BJ

Hood, L

Li, LH

机构：

[1] Univ Washington, Div Genet & Dev, Dept Mol Biotechnol, Seattle, WA 98195 USA

[2] Univ Washington, Div Genet & Dev, Stowers Inst Med Res, Seattle, WA 98195 USA

[3] Univ Washington, Div Genet & Dev, Dept Pediat, Seattle, WA 98195 USA

来源：

GENOMICS | 2000年 / 63卷 / 01期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1006/geno.1999.6045

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The genomic sequence of the human Jagged2 (JAG2) gene, which encodes a ligand for the Notch receptors, was determined. The 30-kb DNA sequence spanning the JAG2 gene contains 26 exons and a putative promoter region. Several potential binding sites for transcription factors, including NF-kappa b, E47, E12, E2F, Ets-1, MyoD, and OCT-1, were found in the human JAG2 promoter region. The JAG2 gene was also mapped to the chromosomal region 14q32 using fluorescence in situ hybridization. (C) 2000 Academic Press.

引用

页码：133 / 138

页数：6

共 54 条

[1] Notch signaling: Cell fate control and signal integration in development [J].