Characterization of ciprofloxacin liposomes: derivative ultraviolet spectrophotometric determinations

被引：21

作者：

Gursoy, A

Senyucel, B

机构：

[1] Dept. of Pharmaceutical Technology, Faculty of Pharmacy, Marmara University, 81010, Haydarpaşa, Istanbul

来源：

JOURNAL OF MICROENCAPSULATION | 1997年 / 14卷 / 06期

关键词：

ciprofloxacin; liposome entrapment; drug release; derivative spectrophotometry;

D O I：

10.3109/02652049709006827

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Neutral, (-) and (+) charged CF encapsulated liposome formulations prepared with EPC:Chol and DPPC:Chol lipids were investigated for their loading capacity, encapsulation % and release properties. CF amounts in the liposomes were estimated using derivative UV spectroscopy. Among the liposome formulations DPPC:Chol and EPC:Chol neutral formulations had a significantly higher loading capacity and slowest release rate compared with (-) and (+) charged liposomes. The derivative UV spectroscopy was found to be an easy and sensitive method for direct estimation of CF in liposomes.

引用

页码：769 / 776

页数：8

共 11 条

[1] NEGATIVE STAINING OF PHOSPHOLIPIDS + THEIR STRUCTURAL MODIFICATION BY-SURFACE ACTIVE AGENTS AS OBSERVED IN ELECTRON MICROSCOPE [J].