Role of epigenetic regulatory mechanisms in neonatal hypoxic-ischemic brain injury

被引：9

作者：

Kumral, Abdullah ^{[1
]}

Tuzun, Funda ^{[1
]}

Yesilirmak, Didem ^{[1
]}

Duman, Nuray ^{[1
]}

Ozkan, Hasan ^{[1
]}

机构：

[1] Dokuz Eylul Univ, Fac Med, Dept Pediat, Subdiv Neonatol, Izmir, Turkey

来源：

MEDICAL HYPOTHESES | 2009年 / 72卷 / 06期

关键词：

HISTONE DEACETYLASE; CEREBRAL-ISCHEMIA; GENE-EXPRESSION; VALPROIC ACID; INHIBITION; NEURONS; DAMAGE;

D O I：

10.1016/j.mehy.2008.10.032

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Hypoxic-ischemic brain injury is an important cause of neonatal mortality and subsequent serious neurological sequel. in neonatal brain the severity of hypoxic injury varies most probably due to the effects of multiple protective or deleterious factors. But the mechanisms under this difference are still not full understood. In recent years, some evidence has been found supporting the involvement of epigenetic mechanisms in many neurodegenerative diseases and stroke. We hypothesised that epigenetic mechanisms have been also involved in neonatal hypoxic-ischemic brain injury possibly by suppression of ischemia-induced cerebral inflammation and changing the expression of proapoptotic-antiapoptotic genes. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：692 / 693

页数：2

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