Stem cell therapy for human neurodegenerative disorders - how to make it work

被引：724

作者：

Lindvall, O ^{[1
]}

Kokaia, Z

Martinez-Serrano, A

机构：

[1] Univ Lund Hosp, Wallenberg Neurosci Ctr, Dept Clin Neurosci, Sect Restorat Neurol,Lab Neurogenesis & Cell Ther, SE-22184 Lund, Sweden

[2] Lund Strateg Res Ctr Stem Cell Biol & Cell Therap, Lund, Sweden

[3] Univ Lund Hosp, Dept Clin Neurosci, Sect Restorat Neurol, Lab Neural Stem Cell Biol, SE-22184 Lund, Sweden

[4] Autonomous Univ Madrid, Ctr Mol Biol Severo Ochoa, Human Neural Stem Cell Biol & Gene Therapy Grp, Madrid 28049, Spain

来源：

NATURE MEDICINE | 2004年 / 10卷 / 07期

关键词：

D O I：

10.1038/nm1064

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recent progress shows that neurons suitable for transplantation can be generated from stem cells in culture, and that the adult brain produces new neurons from its own stem cells in response to injury. These findings raise hope for the development of stem cell therapies in human neurodegenerative disorders. Before clinical trials are initiated, we need to know much more about how to control stem cell proliferation and differentiation into specific phenotypes, induce their integration into existing neural and synaptic circuits, and optimize functional recovery in animal models closely resembling the human disease.

引用

页码：S42 / S50

页数：9

共 111 条

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