U-turns and regulatory RNAs

被引:56
作者
Franch, T [1 ]
Gerdes, K [1 ]
机构
[1] Univ So Denmark, Dept Biochem & Mol Biol, DK-5230 Odense M, Denmark
关键词
D O I
10.1016/S1369-5274(00)00069-2
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Conventional antisense RNAs, such as those controlling plasmid replication and maintenance, inhibit the function of their target RNAs rapidly and efficiently Novel findings show that a common Ii-turn loop structure mediates fast RNA pairing in the majority of these RNA controlled systems. Usually, an antisense RNA regulates a single, cognate target RNA only. Recent reports, however, show that antisense RNAs can act as promiscuous regulators that control multiple genes in concert to integrate complex physiological responses in Escherichia coli.
引用
收藏
页码:159 / 164
页数:6
相关论文
共 47 条
[1]   The Escherichia coli OxyS regulatory RNA represses fhlA translation by blocking ribosome binding [J].
Altuvia, S ;
Zhang, AX ;
Argaman, L ;
Tiwari, A ;
Storz, G .
EMBO JOURNAL, 1998, 17 (20) :6069-6075
[2]   A small, stable RNA induced by oxidative stress: Role as a pleiotropic regulator and antimutator [J].
Altuvia, S ;
WeinsteinFischer, D ;
Zhang, AX ;
Postow, L ;
Storz, G .
CELL, 1997, 90 (01) :43-53
[3]   Structural basis for binding of the plasmid ColIb-P9 antisense Inc RNA to its target RNA with the 5′-rUUGGCG-3′ motif in the loop sequence [J].
Asano, K ;
Niimi, T ;
Yokoyama, S ;
Mizobuchi, K .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (19) :11826-11838
[4]   An RNA pseudoknot as the molecular switch for translation of the repZ gene encoding the replication initiator of IncIα plasmid ColIb-P9 [J].
Asano, K ;
Mizobuchi, K .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (19) :11815-11825
[5]   The uridine in "U-turn": Contributions to tRNA-ribosomal binding [J].
Ashraf, SS ;
Ansari, G ;
Guenther, R ;
Sochacka, E ;
Malkiewicz, A ;
Agris, PF .
RNA, 1999, 5 (04) :503-511
[6]   ANTISENSE RNA-MEDIATED TRANSCRIPTIONAL ATTENUATION OCCURS FASTER THAN STABLE ANTISENSE/TARGET RNA PAIRING - AN IN-VITRO STUDY OF PLASMID PIP501 [J].
BRANTL, S ;
WAGNER, EGH .
EMBO JOURNAL, 1994, 13 (15) :3599-3607
[7]  
BUJALOWSKI W, 1966, BIOCHEMISTRY-US, V25, P6372
[8]  
Chin K, 1999, NAT STRUCT BIOL, V6, P1055
[9]   POSTTRANSCRIPTIONAL REPRESSION OF ESCHERICHIA-COLI OMPF PROTEIN IN RESPONSE TO REDOX STRESS - POSITIVE CONTROL OF THE MICF ANTISENSE RNA BY THE SOXRS LOCUS [J].
CHOU, JH ;
GREENBERG, JT ;
DEMPLE, B .
JOURNAL OF BACTERIOLOGY, 1993, 175 (04) :1026-1031
[10]   IDENTIFICATION OF A GLOBAL REPRESSOR GENE, RSMA, OF ERWINIA-CAVOTAVORA SUBSP CAROTOVORA THAT CONTROLS EXTRACELLULAR ENZYMES, N-(3-OXOHEXANOYL)-L-HOMOSERINE LACTONE, AND PATHOGENICITY IN SOFT-ROTTING ERWINIA SPP [J].
CUI, Y ;
CHATTERJEE, A ;
LIU, Y ;
DUMENYO, CK ;
CHATTERJEE, AK .
JOURNAL OF BACTERIOLOGY, 1995, 177 (17) :5108-5115