Antibacterial Activity of Methyl Gallate Isolated from Galla Rhois or Carvacrol Combined with Nalidixic Acid Against Nalidixic Acid Resistant Bacteria

被引：86

作者：

Choi, Jang-Gi ^{[1
]}

Kang, Ok-Hwa ^{[1
]}

Lee, Young-Seob ^{[1
]}

Oh, You-Chang ^{[1
]}

Chae, Hee-Sung ^{[1
]}

Jang, Hye-Jin ^{[1
]}

Shin, Dong-Won ^{[2
]}

Kwon, Dong-Yeul ^{[1
]}

机构：

[1] Wonkwang Univ, Coll Pharm, Dept Oriental Pharm, Wonkwang Oriental Med Res Inst, Jeonbuk 570749, South Korea

[2] Sunchon Natl Univ, Dept Oriental Med Resources, Jeonnam 540742, South Korea

来源：

MOLECULES | 2009年 / 14卷 / 05期

关键词：

Nalidixic acid-resistant bacteria; methyl gallate; carvacrol; antibacterial activity; combination; IN-VITRO; ESSENTIAL OIL; GROWTH; COMBINATION; MODE;

D O I：

10.3390/molecules14051773

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Methyl gallate is a major component of Galla Rhois, as carvacrol is of oregano essential oils. Both have shown good antibacterial activity against intestinal bacteria. This study investigated the antibacterial activities of nalidixic acid in combination with methyl gallate and carvacrol against nalidixic acid resistant bacteria. The combined effect of nalidixic acid with methyl gallate and carvacrol was evaluated using the checkerboard method to obtain a fractional inhibitory concentration index. The results showed that the combinations of nalidixic acid + methyl gallate/carvacrol improved nalidixic acid resistant pathogenic bacteria inhibition with synergy or partial synergy activity. Thus, a strong bactericidal effect of the drug combinations was observed. In vitro data thus suggested that nalidixic acid combined with methyl gallate and carvacrol may be microbiologically beneficial, rather than antagonists.

引用

页码：1773 / 1780

页数：8

共 24 条

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