Synthesis of TDP-3-amino-3,4,6-trideoxy-α-D-xylo-hexopyranose -: The immediate precursor of TDP-α-D-desosamine

被引：8

作者：

Chang, CWT

Liu, HW ^{[1
]}

机构：

[1] Univ Texas, Coll Pharm, Div Med Chem, Austin, TX 78712 USA

[2] Univ Texas, Dept Chem & Biochem, Austin, TX 78712 USA

[3] Univ Minnesota, Dept Chem, Minneapolis, MN USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2002年 / 12卷 / 11期

关键词：

D O I：

10.1016/S0960-894X(02)00209-3

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A synthetic pathway producing the title compound starting from methyl alpha-D-glucose is described. This compound was shown to be a substrate for DesVI an AdoMet-dependent methyltransferase which catalyzes N,N-dimethylation of the title compound to give a biological significant unusual sugar, desosamine. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：1493 / 1496

页数：4

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