Hyper-Recombination, Diversity, and Antibiotic Resistance in Pneumococcus

被引：132

作者：

Hanage, William Paul ^{[1
]}

Fraser, Christophe ^{[1
]}

Tang, Jing ^{[2
]}

Connor, Thomas Richard ^{[1
]}

Corander, Jukka ^{[2
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Dept Infect Dis Epidemiol, London W2 1PG, England

[2] Abo Akad Univ, Dept Math, FI-20500 Turku, Finland

来源：

SCIENCE | 2009年 / 324卷 / 5933期

基金：

芬兰科学院; 英国生物技术与生命科学研究理事会;

关键词：

BINDING PROTEIN GENES; STREPTOCOCCUS-PNEUMONIAE; PENICILLIN RESISTANCE; POPULATION-STRUCTURE; HORIZONTAL TRANSFER; CONJUGATE VACCINE; BAYESIAN-ANALYSIS; SEROTYPES; EVOLUTION; STRAINS;

D O I：

10.1126/science.1171908

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Streptococcus pneumoniae is a pathogen of global importance that frequently transfers genetic material between strains and on occasion across species boundaries. In an analysis of 1930 pneumococcal genotypes from six housekeeping genes and 94 genotypes from related species, we identified mosaic genotypes representing admixture between populations and found that these were significantly associated with resistance to several classes of antibiotics. We hypothesize that these observations result from a history of hyper-recombination, which means that these strains are more likely to acquire both divergent genetic material and resistance determinants. This could have consequences for the reemergence of drug resistance after pneumococcal vaccination and also for our understanding of diversification and speciation in recombinogenic bacteria.

引用

页码：1454 / 1457

页数：4

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