A single nucleotide polymorphism in exon 1 of cytotoxic T-lymphocyte-associated-4 (CTLA-4) is not associated with rheumatoid arthritis

被引:41
作者
Barton, A [1 ]
Myerscough, A
John, S
Gonzalez-Gay, M
Ollier, W
Worthington, J
机构
[1] Univ Manchester, ARC Epidemiol Unit, Manchester M13 9PL, Lancs, England
[2] Hosp Xeral Calde, Div Rheumatol, Lugo, Spain
关键词
CTLA-4; SNP; rheumatoid arthritis; susceptibility locus; autoimmunity; genetic;
D O I
10.1093/rheumatology/39.1.63
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background. Rheumatoid arthritis (RA) is an oligogenic disease for which only one susceptibility locus has been identified to date. Genes involved in T-cell regulation are potential candidates. Association to cytotoxic T-lymphocyte-associated-4 (CTLA-4) protein, a negative regulator of T-cell activation, has previously been described in a subset of German RA patients carrying the HLA DRBI*0401 subtype. Linkage and association with another oligogenic autoimmune disease, insulin-dependent diabetes mellitus, has also been described in a Spanish population. Objective. To investigate the association of CTLA-4 with RA in Spanish and UK subjects. Methods. Caucasoid UK RA patients (n = 192), UK controls (n = 96), Spanish RA patients (n = 136) and Spanish controls (it = 144) n ere typed for an A/G bi-allelic polymorphism in exon 1 of CTLA-4 using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) (enzyme). Results. No significant differences in the frequency of the G allele or the GG genotype were found in either the UK or Spanish RA patients compared with controls. Conclusion. No significant evidence was found of an association between RA and CTLA-4.
引用
收藏
页码:63 / 66
页数:4
相关论文
共 14 条
[1]  
ARNETT FC, 1987, ARTHRITIS RHEUM, V31, P315
[2]   CTLA4 alanine-17 confers genetic susceptibility to Graves' disease and to type 1 diabetes mellitus [J].
Donner, H ;
Rau, H ;
Walfish, PG ;
Braun, J ;
Siegmund, T ;
Finke, R ;
Herwig, J ;
Usadel, KH ;
Badenhoop, K .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1997, 82 (01) :143-146
[3]  
Forre O, 1997, ARTHRITIS RHEUM, V40, P1264
[4]  
HARPER K, 1991, J IMMUNOL, V147, P1037
[5]  
John S, 1997, J RHEUMATOL, V24, P199
[6]   THE COEXISTENCE OF SYSTEMIC LUPUS-ERYTHEMATOSUS WITH OTHER AUTOIMMUNE-DISEASES - THE KALEIDOSCOPE OF AUTOIMMUNITY [J].
LORBER, M ;
GERSHWIN, ME ;
SHOENFELD, Y .
SEMINARS IN ARTHRITIS AND RHEUMATISM, 1994, 24 (02) :105-113
[7]  
MACGREGOR AJ, 1994, BR J RHEUMATOL S1, V33, P1583
[8]   The CTLA-4 gene region of chromosome 2q33 is linked to, and associated with, type 1 diabetes [J].
Nistico, L ;
Buzzetti, R ;
Pritchard, LE ;
VanderAuwera, B ;
Giovannini, C ;
Bosi, E ;
Larrad, MTM ;
Rios, MS ;
Chow, CC ;
Cockram, CS ;
Jacobs, K ;
Mijovic, C ;
Bain, SC ;
Barnett, AH ;
Vandewalle, CL ;
Schuit, F ;
Gorus, FK ;
Tosi, R ;
Pozzilli, P ;
Todd, JA .
HUMAN MOLECULAR GENETICS, 1996, 5 (07) :1075-1080
[9]   CTLA4 codon 17 dimorphism in patients with rheumatoid arthritis [J].
Seidl, C ;
Donner, H ;
Fischer, B ;
Usadel, KH ;
Seifried, E ;
Kaltwasser, JP ;
Badenhoop, K .
TISSUE ANTIGENS, 1998, 51 (01) :62-66
[10]  
SILMAN AJ, 1993, BRIT J RHEUMATOL, V32, P903