Reagentless biosensing using electrochemical impedance spectroscopy

被引：55

作者：

Farace, G

Lillie, G

Hianik, T

Payne, P

Vadgama, P

机构：

[1] Univ London Queen Mary & Westfield Coll, IRC Biomed Mat, London E1 4NS, England

[2] Univ Manchester, Hope Hosp, Manchester M13 9PL, Lancs, England

[3] Comenius Univ, Fac Math Phys & Comp Sci, Bratislava 84215, Slovakia

[4] UMIST, Dept Instrumentat & Analyt Sci, Manchester M60 1QD, Lancs, England

来源：

BIOELECTROCHEMISTRY | 2002年 / 55卷 / 1-2期

基金：

英国工程与自然科学研究理事会;

关键词：

biosensor; immunoassay; DNA; poly (pyrrole); reagentless;

D O I：

10.1016/S1567-5394(01)00166-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The use of electrochemical impedance spectroscopy (EIS) and the conducting polymer, poly (pyrrole), as an integrated recognition and transduction system for reagentless biosensor systems was demonstrated with two different systems. The first system being an immunoassay for detection of luteinising hormone (LH) with the antibody being entrapped with in the poly (pyrrole) matrix and the second, a construct for DNA hybridisation discrimination able to differentiate single- and double-stranded DNA based on the interaction of the DNA with poly (pyrrole). (C) 2002 Elsevier Science B.V. All rights reserved.

引用

页码：1 / 3

页数：3