Effect of melatonin and electroacupuncture (EA) on NK cell activity, interleukin-2 production and POMC-derived peptides in traumatic rats

被引：9

作者：

Huang, YS ^{[1
]}

Jiang, JW ^{[1
]}

Wu, GC ^{[1
]}

Cao, XD ^{[1
]}

机构：

[1] Fudan Univ, Coll Med, WHO,Dept Neurobiol,Natl Key Lab Med Neurobiol, Collaborating Ctr Tradit Med,Inst Acupuncture Res, Shanghai 200032, Peoples R China

来源：

ACUPUNCTURE & ELECTRO-THERAPEUTICS RESEARCH | 2002年 / 27卷 / 02期

关键词：

melatonin; electroacupuncture; surgical trauma; natural killer cell activity; interleukin-2; beta-endorphin; ACTH;

D O I：

10.3727/036012902816026077

中图分类号：

R [医药、卫生];

学科分类号：

10 [医学];

摘要：

The present study was to evaluate the effect of melatonin(MT) and EA on the cytotoxic activity of natural killer(NK) cells, the dynamic changes of the induction of interleukin-2(IL-2) and the content of POMC-derived peptides, beta-endorphins (betaE) and ACTH in spleen lymphocytes and in plasma of traumatic rats. The results showed that intraperitioneal (i.p.) injection of MT was able to recover the lower levels of NK cell activity and the induction of IL-2 production; MT could also decrease the higher betaE and ACTH levels induced by trauma in spleen lymphocytes and plasma. EA needling of Zusanli(St.36) and Lanwei(Extra.37) points obviously improved the inimunosuppression produced by trauma and antagonized the elevation of PE and ACTH contents induced by trauma stress in spleen lymphocytes and plasma. MT + EA could further modulate the depressed immune function, and there was a significant difference compared with MT (i.p.) or EA alone. MT + EA group further decreased the PE and ACTH contents in immune cells and plasma. Yet, the mechanisms of the attenuation of MT and EA on immunosuppression induced by trauma need further study.

引用

页码：95 / 105

页数：11

共 30 条

[1]

Melatonin: immune modulation of spleen cells in young, middle-aged and senescent mice [J].