The role of Cdx genes in the mammalian gut

被引:75
作者
Beck, F [1 ]
机构
[1] Univ Leicester, Dept Biochem, Leicester LE1 7RH, Leics, England
关键词
D O I
10.1136/gut.2003.038240
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Cdx genes are important in pattern formation during the development of the gut and may well contribute to the balance between differentiation and cell renewal in the mature intestine.
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收藏
页码:1394 / 1396
页数:3
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共 22 条
[1]   Colonic polyposis caused by mTOR-mediated chromosomal instability in Apc+/Δ716 Cdx2+/- compound mutant mice [J].
Aoki, K ;
Tamai, Y ;
Horiike, S ;
Oshima, M ;
Taketo, MM .
NATURE GENETICS, 2003, 35 (04) :323-330
[2]   A study of regional gut endoderm potency by analysis of Cdx2 null mutant chimaeric mice [J].
Beck, F ;
Chawengsaksophak, K ;
Luckett, J ;
Giblett, S ;
Tucci, J ;
Brown, J ;
Poulsom, R ;
Jeffery, R ;
Wright, NA .
DEVELOPMENTAL BIOLOGY, 2003, 255 (02) :399-406
[3]   Reprogramming of intestinal differentiation and intercalary regeneration in Cdx2 mutant mice [J].
Beck, F ;
Chawengsaksophak, K ;
Waring, P ;
Playford, RJ ;
Furness, JB .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (13) :7318-7323
[4]   EXPRESSION OF CDX-2 IN THE MOUSE EMBRYO AND PLACENTA - POSSIBLE ROLE IN PATTERNING OF THE EXTRAEMBRYONIC MEMBRANES [J].
BECK, F ;
ERLER, T ;
RUSSELL, A ;
JAMES, R .
DEVELOPMENTAL DYNAMICS, 1995, 204 (03) :219-227
[5]   The Cdx2 homeobox gene has a tumour suppressor function in the distal colon in addition to a homeotic role during gut development [J].
Bonhomme, C ;
Duluc, I ;
Martin, E ;
Chawengsaksophak, K ;
Chenard, MP ;
Kedinger, M ;
Beck, F ;
Freund, JN ;
Domon-Dell, C .
GUT, 2003, 52 (10) :1465-1471
[6]   The ParaHox gene cluster is an evolutionary sister of the Hox gene cluster [J].
Brooke, NM ;
Garcia-Fernàndez, J ;
Holland, PWH .
NATURE, 1998, 392 (6679) :920-922
[7]  
BURKE AC, 1995, DEVELOPMENT, V121, P333
[8]   ALTERING THE GENOME BY HOMOLOGOUS RECOMBINATION [J].
CAPECCHI, MR .
SCIENCE, 1989, 244 (4910) :1288-1292
[9]   Cdx2 is essential for axial elongation in mouse development [J].
Chawengsaksophak, K ;
de Graaff, W ;
Rossant, J ;
Deschamps, J ;
Beck, F .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (20) :7641-7645
[10]   Homeosis and intestinal tumours in Cdx2 mutant mice [J].
Chawengsaksophak, K ;
James, R ;
Hammond, VE ;
Kontgen, F ;
Beck, F .
NATURE, 1997, 386 (6620) :84-87