CD148, a membrane protein tyrosine phosphatase, is able to induce tyrosine phosphorylation on human lymphocytes

被引：11

作者：

Palou, E ^{[1
]}

delaFuenteGarcia, MA ^{[1
]}

Nicolas, JM ^{[1
]}

Vilardell, C ^{[1
]}

Vives, J ^{[1
]}

Gaya, A ^{[1
]}

机构：

[1] HOSP CLIN BARCELONA,MED INTERNA SERV,BARCELONA,SPAIN

来源：

IMMUNOLOGY LETTERS | 1997年 / 57卷 / 1-3期

关键词：

protein kinases/phosphatases; signal transduction; cell surface molecules; T-lymphocytes;

D O I：

10.1016/S0165-2478(97)00069-2

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

CD148 is a new cluster of differentiation defined in the VI International Workshop on Leucocyte Differentiation Antigens. It has been identified as the hematopoietic form of a formerly described membrane protein tyrosine phosphatase called HPTPeta/DEP-1. Previous data have demonstrated that this molecule is able to give rise to [Ca2+](i) increase. In the present work we show its capability to induce protein tyrosine phosphorylation in human lymphocytes in spite of its intrinsic protein tyrosine phosphatase activity. The induction of kinase activity suggests the involvement of some protein tyrosine kinase based signaling pathway. The activation of this postulated kinase could be carried out through a direct association or via an adapter molecule. (C) 1997 Elsevier Science B.V.

引用

页码：101 / 103

页数：3

共 12 条

[1] Protein tyrosine phosphatases in T-cell development, apoptosis and signalling [J].