Cellular longevity: role of apoptosis and replicative senescence

被引：39

作者：

Bree, RT

Stenson-Cox, C

Grealy, M

Byrnes, L

Gorman, AM

Samali, A

机构：

[1] Natl Univ Ireland, Dept Biochem, Galway, Ireland

[2] Natl Univ Ireland, Natl Ctr Biomed Engn Sci, Galway, Ireland

来源：

BIOGERONTOLOGY | 2002年 / 3卷 / 04期

关键词：

antioxidants; apoptosis; heat shock proteins; oxidative stress; telomeres and telomerase;

D O I：

10.1023/A:1016299812327

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Cellular longevity refers to the lifespan of an individual cell. Normal cells have a finite lifespan and typically die by undergoing apoptosis, or enter into a state of irreversible growth arrest, termed replicative senescence, at the end of that lifespan. The lifespan of a cell is a balance between pro-survival/anti-apoptotic and pro-apoptotic death-promoting factors. The role of heat shock proteins, Bcl-2 family members, antioxidant molecules, and telomere length and telomerase activity in the regulation of apoptosis and replicative senescence, will be discussed.

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页码：195 / 206

页数：12

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