Acupuncture increases cell proliferation and neuropeptide Y expression in dentate gyrus of streptozotocin-induced diabetic rats

被引：41

作者：

Kim, EH

Jang, MH

Shin, MC

Lim, BV

Kim, HB

Kim, YJ

Chung, JH

Kim, CJ

机构：

[1] Kyung Hee Univ, Coll Med, Dept Physiol, Seoul 130701, South Korea

[2] Semyung Univ, Coll Oriental Med, Dept Meridianol, Chungbuk, South Korea

[3] Kyung Hee Univ, Coll Med, Dept Pharmacol, Seoul, South Korea

来源：

NEUROSCIENCE LETTERS | 2002年 / 327卷 / 01期

关键词：

acupuncture; streptozotocin; diabetes; cell proliferation; neuropeptide Y; dentate gyrus;

D O I：

10.1016/S0304-3940(02)00372-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In this study, effects of acupuncture at Zusanli acupoint on cell proliferation and expression of neuropeptide Y (NPY) in the dentate gyrus (DG) of streptozotocin-induced diabetic rats were investigated. Sprague-Dawley rats were divided into six groups: the control group, the non-diabetic and Zusanli-acupunctured group, the non-diabetic and non-acupoint-acupunctured group, the streptozotocin-induced-diabetes group, the streptozotocin-induced-diabetes and Zusanli-acupunctured group, and the streptozotocin-induced-diabetes and non-acupoint-acupunctured group. In the streptozotocin-induced diabetes group, the mean 5-bromo-2'-deoxyuridine-positive and NPY-positive cell counts in the DG were significantly decreased compared to the control group. Stimulation of the Zusanli resulted in increased cell proliferation and neuropeptide Y levels in the diabetic group. In the present results, it can be suggested that acupuncture may affect cell proliferation in the DG of streptozotocin-induced diabetic rats by regulating neuropeptide Y expression. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：33 / 36

页数：4

共 20 条

[1] Knock-out mice reveal a critical antiepileptic role for neuropeptide Y [J].