Effects of statins on human cerebral cholesterol metabolism and secretion of Alzheimer amyloid peptide

被引：102

作者：

Fassbender, K

Stroick, M

Bertsch, T

Ragoschke, A

Kuehl, S

Walter, S

Walter, J

Brechtel, K

Muehlhauser, F

von Bergmann, K

Lütjohann, D

机构：

[1] Univ Gottingen, Dept Neurol, D-37075 Gottingen, Germany

[2] Univ Heidelberg, Clin Mannheim, Dept Clin Chem, D-6900 Heidelberg, Germany

[3] Univ Heidelberg, Clin Mannheim, Dept Neurol, D-6900 Heidelberg, Germany

[4] Univ Bonn, Dept Clin Pharmacol, D-5300 Bonn, Germany

来源：

NEUROLOGY | 2002年 / 59卷 / 08期

关键词：

D O I：

10.1212/WNL.59.8.1257

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Cerebral cholesterol metabolism has been linked with production of amyloid peptide (Abeta) crucial in AD. The association between use of cholesterol-lowering drugs (statins) and AD disease is currently being intensely discussed. In this case-control study on elderly nondemented subjects, the authors provide the first evidence that statins in clinically relevant dosages indeed affect cerebral cholesterol metabolism. However, these changes were not associated with altered intrathecal secretion of Alzheimer Abeta.

引用

页码：1257 / 1258

页数：2

共 5 条

[1] Simvastatin strongly reduces levels of Alzheimer's disease β-amyloid peptides Aβ42 and Aβ40 in vitro and in vivo
Fassbender, K
Simons, M
Bergmann, C
Stroick, M
Lütjohann, D
Keller, P
Runz, H
Kühl, S
Bertsch, T
von Bergmannn, K
Hennerici, M
Beyreuther, K
Hartmann, T
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (10) : 5856 - 5861
[2] Improved discrimination of AD patients using β-amyloid(1-42) and tau levels in CSF
Hulstaert, F
Blennow, K
Ivanoiu, A
Schoonderwaldt, HC
Riemenschneider, M
De Deyn, PP
Bancher, C
Cras, P
Wiltfang, J
Mehta, PD
Iqbal, K
Pottel, H
Vanmechelen, E
Vanderstichele, H
[J]. NEUROLOGY, 1999, 52 (08) : 1555 - 1562
[3] Statins and the risk of dementia
Jick, H
Zornberg, GL
Jick, SS
Seshadri, S
Drachman, DA
[J]. LANCET, 2000, 356 (9242) : 1627 - 1631
[4] Cholesterol homeostasis in human brain: Evidence for an age-dependent flux of 24S-hydroxycholesterol from the brain into the circulation
Lutjohann, D
Breuer, O
Ahlborg, G
Nennesmo, I
Siden, A
Diczfalusy, U
Bjorkhem, I
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (18) : 9799 - 9804
[5] Cholesterol depletion inhibits the generation of β-amyloid in hippocampal neurons
Simons, M
Keller, P
De Strooper, B
Beyreuther, K
Dotti, CG
Simons, K
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (11) : 6460 - 6464

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