Current concepts in the immunopathogenesis of psoriasis

被引：49

作者：

Lowes, MA

Lew, W

Krueger, JG

机构：

[1] Rockefeller Univ, New York, NY 10021 USA

[2] Yonsei Univ, Coll Med, Yongdong Severance Hosp, Dept Dermatol, Seoul, South Korea

[3] Yonsei Univ, Coll Med, Yongdong Severance Hosp, Cutaneous Biol Res Inst, Seoul, South Korea

来源：

DERMATOLOGIC CLINICS | 2004年 / 22卷 / 04期

关键词：

D O I：

10.1016/j.det.2004.03.010

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

There is much evidence to support the concept that psoriasis is a type 1 autoimmune disease, primarily mediated by interferon gamma and other inflammatory cytokines. There has been renewed interest in the role of components of the innate immune system, however, and it may be that overlap between the innate and acquired arms of the immune system can better explain immunopathogenesis in psoriasis. Relevant cell types, receptors, and immune mediators within these traditional boundaries of the immune system are discussed. Finally, pathogenic contributions from important psoriatic mouse models and recent genomic data using the new gene chip technology are elaborated.

引用

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页码：349 / +

页数：22

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