Selective Enhancement of Rapid Eye Movement Sleep by Deep Brain Stimulation of the Human Pons

被引：78

作者：

Lim, Andrew S. ^{[2
]}

Moro, Elena

Lozano, Andres M. ^{[3
]}

Hamani, Clement ^{[3
]}

Dostrovsky, Jonathan O. ^{[4
]}

Hutchison, William D. ^{[3
,4
]}

Lang, Anthony E.

Wennberg, Richard A.

Murray, Brian J. ^{[1
]}

机构：

[1] Univ Toronto, Div Neurol, Dept Med, Sunnybrook Hlth Sci Ctr, Toronto, ON M4N 3M5, Canada

[2] Harvard Univ, Sch Med, Sleep Disorders Unit, Beth Israel Deaconess Med Ctr, Cambridge, MA 02138 USA

[3] Univ Toronto, Div Neurosurg, Dept Surg, Toronto, ON M4N 3M5, Canada

[4] Univ Toronto, Dept Physiol, Toronto, ON M4N 3M5, Canada

来源：

ANNALS OF NEUROLOGY | 2009年 / 66卷 / 01期

关键词：

PEDUNCULOPONTINE NUCLEUS; REM-SLEEP;

D O I：

10.1002/ana.21631

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Animal studies Suggest chat rapid eye movement (REM) sleep is governed by the interaction of REM-promoting and REM-inhibiting nuclei in the pontomesencephalic tegmentum. The pedunculopontine nucleus is proposed to be REM promoting. Using polysomnography, we studied sleep in five parkinsonian patients undergoing unilateral pedunculopontine nucleus deep brain stimulation (DBS). We demonstrated a near doubling of nocturnal REM sleep between the DBS "off" and DBS "on" states, without significant changes in other sleep states. This represents the first demonstration that DBS can selectively modulate human sleep, and it supports an important role for the pedunculopontine nucleus region in modulating human REM sleep.

引用

页码：110 / 114

页数：5

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