Heterocyclic bibenzimidazole derivatives as topoisomerase I inhibitors

被引：48

作者：

Jin, S

Kim, JS

Sim, SP

Liu, A

Pilch, DS

Liu, LF

LaVoie, EJ ^{[1
]}

机构：

[1] Rutgers State Univ, Dept Pharmaceut Chem, Piscataway, NJ 08854 USA

[2] Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Dept Pharmacol, Piscataway, NJ 08854 USA

[3] Canc Inst New Jersey, New Brunswick, NJ 08901 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2000年 / 10卷 / 08期

关键词：

D O I：

10.1016/S0960-894X(00)00087-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

A series of 2'-heterocyclic derivatives of 5-phenyl-2,5'-1H-bibenzimidazoles were evaluated for topoisomerase I poisoning activity and cytotoxicity. Topo I poisoning activity was associated with 2'-derivatives that possessed a hydrogen atom capable of hydrogen bond formation, suggesting that the interatomic distances between such hydrogen atoms and the heteroatoms on the adjacent benzimidazole influence activity. (C) 2000 Elsevier Science Ltd. All rights reserved.

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页码：719 / 723

页数：5

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