A new approach to functionalised spiropiperidines through tandem RCM and nitrogen-directed reactions

被引：42

作者：

Edwards, AS

Wybrow, RAJ

Johnstone, C

Adams, H

Harrity, JPA ^{[1
]}

机构：

[1] Univ Sheffield, Dept Chem, Sheffield S3 7HF, S Yorkshire, England

[2] AstraZeneca, Dept Med Chem, Macclesfield SK10 4TG, Cheshire, England

来源：

CHEMICAL COMMUNICATIONS | 2002年 / 14期

关键词：

D O I：

10.1039/b203851j

中图分类号：

O6 [化学];

学科分类号：

0703 [化学];

摘要：

The synthesis of a functionalised spiropiperidine via a tandem ring closing metathesis strategy is described, furthermore, the regio- and stereoselective functionalisation of this compound has been achieved through a novel nitrogen-directed epoxidation reaction.

引用

收藏

页码：1542 / 1543

页数：2

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