The origins and functions of dendritic cells and macrophages in the skin

被引：370

作者：

Malissen, Bernard ^{[1
]}

Tamoutounour, Samira ^{[1
]}

Henri, Sandrine ^{[1
]}

机构：

[1] Aix Marseille Univ, Ctr Immunol Marseille Luminy, Inst Natl Sante & Rech Med U1104, CNRS,Unite Mixte Rech 7280, F-13288 Marseille, France

来源：

NATURE REVIEWS IMMUNOLOGY | 2014年 / 14卷 / 06期

关键词：

REGULATORY T-CELLS; MAINTAIN IMMUNE HOMEOSTASIS; LANGERHANS CELLS; STEADY-STATE; CD8(+) T; LYMPH-NODES; CROSS-PRESENTATION; TISSUE-RESIDENT; ANTIGEN; EXPRESSION;

D O I：

10.1038/nri3683

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Immune cell populations in the skin are predominantly comprised of dendritic cells (DCs) and macrophages. A lack of consensus regarding how to define these cell types has hampered research in this area. In this Review, we focus on recent advances that, based on ontogeny and global gene-expression profiles, have succeeded in discriminating DCs from macrophages in the skin. We discuss how these studies have enabled researchers to revisit the origin, diversity and T cell-stimulatory properties of these cells, and have led to unifying principles that extend across tissues and species. By aligning the DC and macrophage subsets that are found in mouse skin with those that are present in human skin, these studies also provide crucial information for developing intradermat vaccines and for managing inflammatory skin conditions.

引用

页码：417 / 428

页数：12

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