Lipase-catalyzed synthesis of vitamin C fatty acid esters

被引：106

作者：

Yan, YC ^{[1
]}

Bornscheuer, UT ^{[1
]}

Schmid, RD ^{[1
]}

机构：

[1] Univ Stuttgart, Inst Tech Biochem, D-70569 Stuttgart, Germany

来源：

BIOTECHNOLOGY LETTERS | 1999年 / 21卷 / 12期

关键词：

antioxidant; ascorbic acid; Candida antarctica B lipase; fatty acid vinyl ester; vitamin C;

D O I：

10.1023/A:1005620125533

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Fatty acid esters of vitamin C (ascorbic acid) where synthesized in a mainly solid-phase system in the presence of small amounts of organic solvent (acetone or t-butanol) catalyzed by immobilized lipase B from Candida antarctica. Highest reaction rates and yields of isolated products were obtained using fatty acid vinyl esters, e.g., 6-O-palmitoyl-L-ascorbic acid was obtained in 91% isolated yield after 48 h. As vitamin C and its esters are very sensitive to oxidation, a mild extraction method for the isolation of reaction products was developed.

引用

页码：1051 / 1054

页数：4

共 7 条

[1]

Bornscheuer U. T, 1999, HYDROLASES ORGANIC S

[2] Lipase-catalyzed solid phase synthesis of sugar fatty acid esters [J].

Cao, LQ ;

Fischer, A ;

Bornscheuer, UT ;

Schmid, RD .

BIOCATALYSIS AND BIOTRANSFORMATION, 1997, 14 (04) :269-283

[3] Effect of the thermodynamic water activity and the reaction medium hydrophobicity on the enzymatic synthesis of ascorbyl palmitate [J].

Humeau, C ;

Girardin, M ;

Rovel, B ;

Miclo, A .

JOURNAL OF BIOTECHNOLOGY, 1998, 63 (01) :1-8

[4] Enzymatic synthesis of fatty acid ascorbyl esters [J].

Humeau, C ;

Girardin, M ;

Rovel, B ;

Miclo, A .

JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC, 1998, 5 (1-4) :19-23

[5] CONTROL OF LIPID OXIDATION IN FISH OIL WITH VARIOUS ANTIOXIDATIVE COMPOUNDS [J].

KAITARANTA, JK .

JOURNAL OF THE AMERICAN OIL CHEMISTS SOCIETY, 1992, 69 (08) :810-813

[6] Pharmacology of oleanolic acid and ursolic acid [J].

Liu, J .

JOURNAL OF ETHNOPHARMACOLOGY, 1995, 49 (02) :57-68

[7] Remarkable enhancement of antioxidant activity of vitamin C in an artificial bilayer by making it lipo-soluble [J].

Liu, XY ;

Guo, FL ;

Wu, LM ;

Liu, YC ;

Liu, ZL .

CHEMISTRY AND PHYSICS OF LIPIDS, 1996, 83 (01) :39-43

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