Aging of marrow stromal (skeletal) stem cells and their contribution to age-related bone loss

被引：80

作者：

Bellantuono, Ilaria ^{[1
]}

Aldahmash, Abdullah ^{[2
]}

Kassem, Moustapha ^{[2
,3
,4
]}

机构：

[1] Univ Sheffield, Acad Unit Bone Biol, Fac Med Dent & Hlth, Sch Med, Sheffield S10 2RX, S Yorkshire, England

[2] King Saud Univ, Stem Cell Unit, Dept Anat, Riyadh, Saudi Arabia

[3] Odense Univ Hosp, Univ Dept Endocrinol, DK-5000 Odense, Denmark

[4] Ctr Med Biotechnol, DK-5000 Odense, Denmark

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE | 2009年 / 1792卷 / 04期

关键词：

Mesenchymal stem cell; Ageing; Marrow stromal cell; Senescence; Telomeres Notch; OSTEOBLAST DIFFERENTIATION; LIFE-SPAN; IN-VITRO; MESENCHYMAL PROGENITORS; OSTEOGENIC CELLS; DONOR AGE; TELOMERASE; TISSUE; IDENTIFICATION; MAINTENANCE;

D O I：

10.1016/j.bbadis.2009.01.008

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Marrow stromal cells (MSC) are thought to be stem cells with osteogenic potential and therefore responsible for the repair and maintenance of the skeleton. Age related bone loss is one of the most prevalent diseases in the elder population. It is controversial whether MSC undergo a process of aging in vivo, leading to decreased ability to form and maintain bone homeostasis with age. In this review we summarize evidence of MSC involvement in age related bone loss and suggest new emerging targets for intervention. Crown Copyright (C) 2009 Published by Elsevier B.V. All rights reserved.

引用

页码：364 / 370

页数：7

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