p62 at the Crossroads of Autophagy, Apoptosis, and Cancer

被引：931

作者：

Moscat, Jorge ^{[1
]}

Diaz-Meco, Maria T. ^{[1
]}

机构：

[1] Univ Cincinnati, Coll Med, Dept Canc & Cell Biol, Cincinnati, OH 45267 USA

来源：

CELL | 2009年 / 137卷 / 06期

关键词：

INTERACTING PROTEIN P62; SIGNALING ADAPTER P62; PAGET-DISEASE; DEGRADATION; MUTATION; OSTEOCLASTOGENESIS; POLYUBIQUITINATION; AGGREGATION; SQSTM1/P62; DEFICIENT;

D O I：

10.1016/j.cell.2009.05.023

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The signaling adaptor p62 is a multidomain protein implicated in the activation of the transcription factor NF-kappa B. Recent findings link p62 activity to the extrinsic apoptosis pathway, and Mathew et al. (2009) now show that the modulation of p62 by autophagy is a key factor in tumorigenesis. These findings place p62 at critical decision points that control cell death and survival.

引用

页码：1001 / 1004

页数：4

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