Angiotensin-converting enzyme 2 inhibits lung injury induced by respiratory syncytial virus

被引：173

作者：

Gu, Hongjing ^{[1
]}

Xie, Zhengde ^{[2
,3
]}

Li, Tieling ^{[4
]}

Zhang, Shaogeng ^{[5
]}

Lai, Chengcai ^{[1
]}

Zhu, Ping ^{[1
]}

Wang, Keyu ^{[1
]}

Han, Lina ^{[4
]}

Duan, Yueqiang ^{[1
]}

Zhao, Zhongpeng ^{[1
]}

Yang, Xiaolan ^{[1
]}

Xing, Li ^{[1
]}

Zhang, Peirui ^{[5
]}

Wang, Zhouhai ^{[5
]}

Li, Ruisheng ^{[5
]}

Yu, Jane J. ^{[6
]}

Wang, Xiliang ^{[1
]}

Yang, Penghui ^{[1
,5
]}

机构：

[1] Beijing Inst Microbiol & Epidemiol, State Key Lab Pathogens & Biosecur, Beijing 100071, Peoples R China

[2] Capital Med Univ, Key Lab Major Dis Children & Natl Key Discipline, Beijing, Peoples R China

[3] Capital Med Univ, Beijing Childrens Hosp, Beijing Pediat Res Inst, Beijing 100045, Peoples R China

[4] Chinese Peoples Liberat Army Gen Hosp, Beijing 1000853, Peoples R China

[5] Beijing302 Hosp, Beijing 100039, Peoples R China

[6] Univ Cincinnati, Coll Med, Dept Internal Med, Div Pulm Crit Care & Sleep Med, 231 Albert Sabin Way,CVC4926, Cincinnati, OH 45267 USA

来源：

SCIENTIFIC REPORTS | 2016年 / 6卷

关键词：

OXIDATIVE STRESS; ACE2; RSV; INFLAMMATION; REGULATOR; BIOMARKER; PROTECTS; DISEASE; ILLNESS; BLOOD;

D O I：

10.1038/srep19840

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Respiratory syncytial virus (RSV) infection is a major cause of severe lower respiratory illness in infants and young children, but the underlying mechanisms responsible for viral pathogenesis have not been fully elucidated. To date, no drugs or vaccines have been employed to improve clinical outcomes for RSV-infected patients. In this paper, we report that angiotensin-converting enzyme-2 (ACE2) protected against severe lung injury induced by RSV infection in an experimental mouse model and in pediatric patients. Moreover, ACE2 deficiency aggravated RSV-associated disease pathogenesis, mainly by its action on the angiotensin II type 1 receptor (AT1R). Furthermore, administration of a recombinant ACE2 protein alleviated the severity of RSV-induced lung injury. These findings demonstrate that ACE2 plays a critical role in preventing RSV-induced lung injury, and suggest that ACE2 is a promising potential therapeutic target in the management of RSV-induced lung disease.

引用

页数：10

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