Remission of relapsing childhood nephrotic syndrome with mycophenolate mofetil

被引:26
作者
Chandra, M [1 ]
Susin, M [1 ]
Abitbol, C [1 ]
机构
[1] NYU, Sch Med, N Shore Univ Hosp, Dept Pediat, Manhasset, NY 11030 USA
关键词
idiopathic nephrotic syndrome; minimal change disease; focal segmental glomerulosclerosis; mycophenolate mofetil;
D O I
10.1007/s004670050047
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
We report a 21-year-old male with childhood-onset familial nephrotic syndrome and frequent relapses who manifested toxicity or treatment resistance to corticosteroids, cyclophosphamide, cyclosporin-A. and tacrolimus. Monotherapy with mycophenolate mofetil (MMF) resulted in maintenance of clinical remission for 14 months without noticeable toxicity, while allowing resolution of steroid-induced side effects. Our observation suggests that MMF may be useful in maintaining remission in nephrotic patients who manifest toxicity to standard immunosuppressive agents.
引用
收藏
页码:224 / 226
页数:3
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