Serum lipopolysaccharide-binding protein prediction of severe bacterial infection in cirrhotic patients with ascites

被引：85

作者：

Albillos, A

de-La-Hera, A

Alvarez-Mon, M

机构：

[1] Univ Alcala De Henares, Dept Med, CSIC,Unidad I&D Asociada, Lab Enfermedades Sistema Inmune & Oncol, Madrid 28871, Spain

[2] Hosp Univ Ramon y Cajal, Serv Gastroenterol, Madrid, Spain

[3] Hosp Univ Principe Asturias, Serv Enfermedades Sistema Inmune & Oncol, Madrid, Spain

来源：

LANCET | 2004年 / 363卷 / 9421期

关键词：

D O I：

10.1016/S0140-6736(04)16206-5

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Serum lipopolysaccharide-binding protein is increased in a subset of non-infected ascitic cirrhotic patients, a finding previously related to bacterial passage from the gut to the circulation without overt infection. We prospectively analysed the risk factors associated with a first episode of severe bacterial infection in 84 ascitic cirrhotics, followed up for a median of 46 weeks. The cumulative probability. of such infection in patients with raised and normal lipopolysaccharide-binding protein was 32.4% and 8.0% (p=0.004), respectively. Increased lipopolysaccharide-binding protein was the only factor independently associated with severe bacterial infection in a multivariate analysis (relative risk 4.49, 95% CI 1.42-14.1). Monitoring of serum lipopolysaccharide-binding protein could, therefore, help to target cirrhotic patients with ascites for antibiotic prophylaxis.

引用

页码：1608 / 1610

页数：3

共 5 条

[1]

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[2]

Zweigner J., Gramm H.J., Singer O.C., Wegscheider K., Schumann R.R., High concentrations of lipopolysaccharide-binding protein in serum of patients with severe sepsis or septic shock inhibit the lipopolysaccharide response in human monocytes, Blood, 98, pp. 3800-3808, (2001)

[3]

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[4]

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[5]

Albillos A., De-La-Hera A., Reyes E., Et al., TNFα expression by activated monocytes and altered T-cell homeostasis in ascitic alcoholic cirrhosis: Amelioration with norfloxacin, J Hepatol

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