Late radiation injury to the temporal lobes: Morphologic evaluation at MR imaging

被引:82
作者
Chan, YL [1 ]
Leung, SF
King, AD
Choi, PHK
Metreweli, C
机构
[1] Chinese Univ Hong Kong, Prince Wales Hosp, Dept Diagnost Radiol & Organ Imaging, Hong Kong, Peoples R China
[2] Chinese Univ Hong Kong, Prince Wales Hosp, Dept Clin Oncol, Hong Kong, Peoples R China
关键词
brain; MR; necrosis; gadolinium; magnetic resonance (MR); pulse sequences; radiations; injurious effects; complications of therapeutic radiology;
D O I
10.1148/radiology.213.3.r99dc07800
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
PURPOSE: To study the morphologic characteristics of late radiation injury to the temporal lobes of the brain on magnetic resonance (MR) images. MATERIALS AND METHODS: This was a prospective study involving 34 patients (age range, 37-72 years) with known radiation injury to the temporal lobes from radiation therapy administered 2-10 years previously for nasopharyngeal carcinoma. MR imaging was performed with T2-weighted gradient- and spin-echo, gradient-recalled echo, T1-weighted spin-echo, fluid-attenuated inversion-recovery, and T1-weighted postcontrast spin-echo sequences. RESULTS: Radiation injury was present in 57 of the 68 temporal lobes. The white matter lesions in radiation-induced injury were predominantly hyperintense on T2-weighted images, but in 37 (65%) of the 57 lobes, foci with heterogeneous signal intensity consistent with necrosis were detected. In the 57 involved lobes, gray matter lesions were detected in 50 (88%); blood-brain barrier disruption based on parenchymal contrast enhancement, in 51 (89%); and hemosiderin deposits, in 30 (53%). There was a significant correlation between white matter necrosis, gray matter lesions, and blood-brain barrier disruption, all of which were located mainly in the inferior temporal lobes that received the highest radiation dose. CONCLUSION: The lesion components of radiation-induced injury to the temporal lobes at MR imaging were more varied than have been previously described. In addition to the classic white matter lesions, gray matter lesions, blood-brain barrier disruption, and hemosiderin deposition also were frequently seen.
引用
收藏
页码:800 / 807
页数:8
相关论文
共 31 条
[1]  
BURGER PC, 1991, RAD INJURY NERVOUS S, P191
[2]   TIME-RELATED AND DOSE-RELATED CHANGES IN THE WHITE MATTER OF THE RAT-BRAIN AFTER SINGLE DOSES OF X-RAYS [J].
CALVO, W ;
HOPEWELL, JW ;
REINHOLD, HS ;
YEUNG, TK .
BRITISH JOURNAL OF RADIOLOGY, 1988, 61 (731) :1043-1052
[3]   ADVERSE-EFFECTS OF BRAIN IRRADIATION CORRELATED WITH MR AND CT IMAGING [J].
CONSTINE, LS ;
KONSKI, A ;
EKHOLM, S ;
MCDONALD, S ;
RUBIN, P .
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1988, 15 (02) :319-330
[4]   MAGNETIC-RESONANCE-IMAGING OF CRANIAL RADIATION LESIONS [J].
CURRAN, WJ ;
HECHTLEAVITT, C ;
SCHUT, L ;
ZIMMERMAN, RA ;
NELSON, DF .
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1987, 13 (07) :1093-1098
[5]  
DECK MDF, 1980, RAD DAMAGE NERVOUS S, P107
[6]   BRAIN RADIATION LESIONS - MR IMAGING [J].
DOOMS, GC ;
HECHT, S ;
BRANTZAWADZKI, M ;
BERTHIAUME, Y ;
NORMAN, D ;
NEWTON, TH .
RADIOLOGY, 1986, 158 (01) :149-155
[7]  
FLEISS JL, 1971, PSYCHOL BULL, V76, P378, DOI 10.1037/h0031619
[8]   RADIATION-INDUCED TELANGIECTASIA IN THE BRAIN SIMULATES CRYPTIC VASCULAR MALFORMATIONS AT MR-IMAGING [J].
GAENSLER, EHL ;
DILLON, WP ;
EDWARDS, MSB ;
LARSON, DA ;
ROSENAU, W ;
WILSON, CB .
RADIOLOGY, 1994, 193 (03) :629-636
[9]  
Gutin P., 1991, RAD INJURY NERVOUS S, P271
[10]  
Ho JHC., 1982, TREATMENT CANCER, P249