Polymer-supported BINOL ligand for the titanium-catalyzed diethylzinc addition to aldehydes: A remarkable positive influence of the support on the enantioselectivity of the catalyst

被引：143

作者：

Yang, XW

Sheng, JH

Da, CS

Wang, HS

Su, W

Wang, R ^{[1
]}

Chan, ASC

机构：

[1] Lanzhou Univ, Union Lab Asymmetr Synth, Lanzhou 730000, Peoples R China

[2] Lanzhou Univ, Sch Life Sci, Lanzhou 730000, Peoples R China

[3] Hong Kong Polytech Univ, Union Lab Asymmetr Synth, Hong Kong, Peoples R China

[4] Hong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Hong Kong, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2000年 / 65卷 / 02期

关键词：

D O I：

10.1021/jo990771p

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new polymer-supported BINOL (1,1'-Bi-2-naphthol) :was synthesized by coupling of aminomethyl polystyrene resin and (S)-2,2'-dihydroxy-1,1'-binaphthyl-3,3'-dicarboxylic acid. This new ligand was found to be more enantioselective for the asymmetric addition of diethylzinc to aldehydes than its "free" analog [Ti(BINOL)(PrO2)-Pr-i]. A range of 57-99% ee's as well as 78-97% yields was obtained, and: the electronic properties of the enantioselectivity were also observed.

引用

页码：295 / 296

页数：2

共 24 条

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