Impact of Family Hypertension History on Exercise-Induced Cardiac Remodeling

被引:25
作者
Baggish, Aaron L. [1 ]
Weiner, Rory B. [1 ]
Yared, Kibar [1 ]
Wang, Francis [2 ]
Kupperman, Eli [2 ]
Hutter, Adolph M., Jr. [1 ]
Picard, Michael H. [1 ]
Wood, Malissa J. [1 ]
机构
[1] Massachusetts Gen Hosp, Div Cardiol, Boston, MA 02114 USA
[2] Harvard Univ, Univ Hlth Serv, Cambridge, MA 02138 USA
关键词
LEFT-VENTRICULAR STRUCTURE; CONVERTING ENZYME GENE; POLYMORPHISM; MASS; ASSOCIATION; COMMITTEE; YOUNG;
D O I
10.1016/j.amjcard.2009.02.052
中图分类号
R5 [内科学];
学科分类号
100201 [内科学];
摘要
Left ventricular (LV) hypertrophy is a well-established, but highly variable, finding among exercise-trained persons. The causes for the variability in LV remodeling in response to exercise training remain incompletely understood. The present study sought to determine whether a family history of hypertension is a determinant of the cardiac response to exercise training. The cardiac parameters in 60 collegiate rowers (30 men/30 women; age 19.8 +/- 1.1 years) with (family history positive [FH+], n = 22) and without (family history negative [FH-], n = 38) a FH of hypertension were studied with echocardiography before and after 90 days of rowing training. The LV mass increased significantly in both groups. However, the LV mass increased significantly more in FH- persons (Delta 17 +/- 5 g/m(2)) than in FH+ persons (Delta 9 +/- 6 g/m(2), p <0.001) with distinctly differently patterns of LV hypertrophy between the 2 groups. FH- athletes experienced eccentric LV hypertrophy (relative wall thickness index 0.39 +/- 0.4) characterized by LV dilation. In contrast, FH+ athletes developed concentric LV hypertrophy (relative wall thickness index 0.44 +/- 0.3; p <0.001) characterized by LV wall thickening. Furthermore, the eccentric LV remodeling in FH- athletes was associated with a more robust enhancement of LV diastolic function than the concentric LV remodeling that occurred in FH+ athletes. In conclusion, these findings suggest that patterns of exercise-induced LV remodeling are strongly associated with FH history status. (c) 2009 Elsevier Inc. (Am J Cardiol 2009;104:101-106)
引用
收藏
页码:101 / 106
页数:6
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