Fibril-forming model synthetic peptides containing 3-aminophenylacetic acid

被引：25

作者：

Maji, SK ^{[1
]}

Haldar, D ^{[1
]}

Banerjee, A ^{[1
]}

机构：

[1] Indian Assoc Cultivat Sci, Dept Biol Chem, Kolkata 700032, W Bengal, India

来源：

TETRAHEDRON | 2002年 / 58卷 / 43期

关键词：

amyloid fibril; 3-aminophenylacetic acid; Aib; beta-sheet;

D O I：

10.1016/S0040-4020(02)01093-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The FIF-IR, H-1 NMR, electrospray mass spectrometry studies of several dipeptides containing 3-APA (3-aminophenylacetic acid) and Aib/Val/Pro, revealed that all peptides share a common structural feature, an extended backbone conformation and they form the intermolecular hydrogen bonded supramolecular beta-sheet structure in the solid state. The SEM images of all peptides exhibit amyloid-like fibrils, reminiscent of many neurodegenerative diseases like Alzheimer's, Prion-protein diseases. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：8695 / 8702

页数：8

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