Prediction and Interaction in Complex Disease Genetics: Experience in Type 1 Diabetes

被引：198

作者：

Clayton, David G. ^{[1
]}

机构：

[1] Univ Cambridge, Juvenile Diabet Res Fdn, Wellcome Trust Diabet & Inflammat Lab, Dept Med Genet,Cambridge Inst Med Res, Cambridge, England

来源：

PLOS GENETICS | 2009年 / 5卷 / 07期

基金：

英国惠康基金;

关键词：

RISK; SUSCEPTIBILITY; EPISTASIS; MODELS; ASSOCIATION; FRAMEWORK; SYNERGISM; MELLITUS; DESIGNS; TRAITS;

D O I：

10.1371/journal.pgen.1000540

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

[No abstract available]

引用

页数：6

共 47 条

[1] Computational analysis of the synergy among multiple interacting genes [J].

Anastassiou, Dimitris .

MOLECULAR SYSTEMS BIOLOGY, 2007, 3 (1)

[2]

[Anonymous], 2002, BBC NEWS 0429

[3]

AZZALINI A, 1984, J ROY STAT SOC B MET, V46, P335

[4]

Barrett J.C., 2009, Nat. Genet

[5]

Bateson W., 1909, MENDELS PRINCIPLES H

[6] A POLYMORPHIC LOCUS NEAR THE HUMAN INSULIN GENE IS ASSOCIATED WITH INSULIN-DEPENDENT DIABETES-MELLITUS [J].

BELL, GI ;

HORITA, S ;

KARAM, JH .

DIABETES, 1984, 33 (02) :176-183

[7] Joint effects of HLA, INS, PTPN22 and CTLA4 genes on the risk of type 1 diabetes [J].

Bjornvold, M. ;

Undlien, D. E. ;

Joner, G. ;

Dahl-Jorgensen, K. ;

Njolstad, P. R. ;

Akselsen, H. E. ;

Gervin, K. ;

Ronningen, K. S. ;

Stene, L. C. .

DIABETOLOGIA, 2008, 51 (04) :589-596

[8] Influence of life stress on depression: Moderation by a polymorphism in the 5-HTT gene [J].

Caspi, A ;

Sugden, K ;

Moffitt, TE ;

Taylor, A ;

Craig, IW ;

Harrington, H ;

McClay, J ;

Mill, J ;

Martin, J ;

Braithwaite, A ;

Poulton, R .

SCIENCE, 2003, 301 (5631) :386-389

[9] Epistasis: what it means, what it doesn't mean, and statistical methods to detect it in humans [J].

Cordell, HJ .

HUMAN MOLECULAR GENETICS, 2002, 11 (20) :2463-2468

[10] INTERPRETATION OF INTERACTION: A REVIEW [J].

De Gonzalez, Amy Berrington ;

Cox, D. R. .

ANNALS OF APPLIED STATISTICS, 2007, 1 (02) :371-385

← 1 2 3 4 5 →