Therapeutic potential of interleukin-15: a myokine involved in muscle wasting and adiposity

被引：44

作者：

Argiles, Josep M. ^{[1
]}

Lopez-Soriano, Francisco J. ^{[1
]}

Busquets, Silvia ^{[1
]}

机构：

[1] Univ Barcelona, Fac Biol, Dept Bioquim & Biol Mol, E-08028 Barcelona, Spain

来源：

DRUG DISCOVERY TODAY | 2009年 / 14卷 / 3-4期

关键词：

TUMOR-BEARING RATS; SKELETAL-MUSCLE; GENE-EXPRESSION; DNA FRAGMENTATION; CELL PROLIFERATION; ENDOTHELIAL-CELLS; CANCER CACHEXIA; IL-2; RECEPTOR; GROWTH-FACTOR; KILLER-CELLS;

D O I：

10.1016/j.drudis.2008.10.010

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Since the discovery of IL-15 and its role in T-cell proliferation in 1994, different studies on the effects of the cytokine on metabolic effects have been performed. These studies have mainly been involved with the metabolic pathways involved in lipid and protein metabolism. The present review summarises the metabolic effects of IL-15 at different target tissues and the possibilities and potential for therapeutic interventions based on the cytokine's roles in obesity and wasting.

引用

页码：208 / 213

页数：6

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