Wound healing effects of nanoemulsion containing clove essential oil

被引：85

作者：

Alam, Prawez ^{[1
]}

Ansari, Mohammad J. ^{[2
]}

Anwer, Md. Khalid ^{[2
]}

Raish, Mohammad ^{[3
]}

Kamal, Yoonus K. T. ^{[1
]}

Shakeel, Faiyaz ^{[4
]}

机构：

[1] Prince Sattam Bin Abdulaziz Univ, Coll Pharm, Dept Pharmacognosy, Al Kharj, Saudi Arabia

[2] Prince Sattam Bin Abdulaziz Univ, Coll Pharm, Dept Pharmaceut, Al Kharj, Saudi Arabia

[3] King Saud Univ, Coll Pharm, Dept Pharmaceut, Riyadh, Saudi Arabia

[4] King Saud Univ, CEBR, Riyadh, Saudi Arabia

来源：

ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY | 2017年 / 45卷 / 03期

关键词：

Clove oil; collagen; histopathology; leucine; nanoemulsion; wound healing; IN-VITRO; LISTERIA-MONOCYTOGENES; EUGENIA-CARYOPHYLLATA; SYZYGIUM-AROMATICUM; DELIVERY; ANTIBACTERIAL; ENHANCEMENT; L;

D O I：

10.3109/21691401.2016.1163716

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 [微生物学]; 090105 [作物生产系统与生态工程];

摘要：

The aim of this study was to investigate the wound healing effects of clove oil (CO) via its encapsulation into nanoemulsion. Optimized nanoemulsion (droplet size of 29.10nm) was selected for wound healing investigation, collagen determination, and histopathological examination in rats. Optimized nanoemulsion presented significant would healing effects in rats as compared to pure CO. Nanoemulsion also presented significant enhancement in leucine content (0.61 mg/g) as compared to pure CO (0.50 mg/g) and negative control (0.31mg/g). Histopathology of nanoemulsion treated rats showed no signs of inflammatory cells. These results suggested that nanoemulsion of CO was safe and nontoxic.

引用

页码：591 / 597

页数：7

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