A mathematical model of drug resistance: Heterogeneous tumors

被引：73

作者：

Panetta, JC

机构：

[1] Mathematics Program, Penn State Erie, Behrend College, Erie, PA 16563-0203, Station Road

来源：

MATHEMATICAL BIOSCIENCES | 1998年 / 147卷 / 01期

关键词：

D O I：

10.1016/S0025-5564(97)00080-1

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A mathematical model is developed to describe the growth and control of a heterogeneous tumor. The main aspect of the model is that it takes into account induced drug resistance. The mathematical model is a system of two ordinary differential equations that describes the growth of the cancer along with the effects of chemotherapy. The model is analyzed to determine what some of the critical parameters are; how we determine an effective treatment; how combination chemotherapy should be delivered; and how this model may help us develop more effective cancer chemotherapeutic treatments. (C) 1998 Elsevier Science Inc.

引用

页码：41 / 61

页数：21

共 17 条

[1] DOSE-RESPONSE CURVES FOR AGENTS THAT IMPAIR CELL REPRODUCTIVE INTEGRITY - RELATION BETWEEN DOSE-RESPONSE CURVES AND DESIGN OF SELECTIVE REGIMENS IN CANCER CHEMOTHERAPY [J].