WWP2: A Multifunctional Ubiquitin Ligase Gene

被引：39

作者：

Chen, Wei ^{[1
]}

Jiang, Xiaofei ^{[2
]}

Luo, Zhuang ^{[3
,4
]}

机构：

[1] Sichuan North Med Coll, Dept Pathophysiol, Nanchong 637100, Peoples R China

[2] Seventh Peoples Hosp Chengdu, Dept Gen Surg, Chengdu 610041, Peoples R China

[3] Kunming Med Univ, Dept Resp Dis, Affiliated Hosp 1, Kunming 650032, Peoples R China

[4] Sichuan Univ, West China Hosp, Dept Resp Med, Chengdu 610041, Peoples R China

来源：

PATHOLOGY & ONCOLOGY RESEARCH | 2014年 / 20卷 / 04期

关键词：

WWP2 (AIP2); Ubiquitylation; Cancer; DOMAIN-CONTAINING PROTEINS; STEM-CELLS; FUNCTIONAL DIVERSITY; NEDD4; FAMILY; E3; LIGASE; CANCER; AUTOINHIBITION; OCT4; DEGRADATION; ACTIVATION;

D O I：

10.1007/s12253-014-9838-y

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

The ubiquitin-proteasome system plays an important role in various celluar processes. WWP2, a recently identified ubiquitin E3 ligase, has been proved a multifunctional gene by degradation a series of targets via ubiquitin-dependent proteasome system, including PETN, Smads, Oct4, EGR2, TIRF and so. Hereafter, we reviewed the recent research process about the function of WWP2.

引用

页码：799 / 803

页数：5

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