Oral squamous cell carcinoma after allogeneic bone marrow transplantation for Fanconi anaemia

被引：43

作者：

Millen, FJ

Rainey, MG

Hows, JM

Burton, PA

Irvine, GH

Swirsky, D

机构：

[1] UNIV BRISTOL,SOUTHMEAD HOSP,DIV TRANSPLANTAT SCI,BRISTOL BS10 5NB,AVON,ENGLAND

[2] SOUTHMEAD GEN HOSP,NHS TRUST,BRISTOL,AVON,ENGLAND

[3] ROYAL POSTGRAD MED SCH,DEPT HAEMATOL,LONDON W12 0HS,ENGLAND

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 1997年 / 99卷 / 02期

关键词：

Fanconi anaemia; squamous cell carcinoma; bone marrow transplantation; immunosuppression; microvascular free flap;

D O I：

10.1046/j.1365-2141.1997.3683184.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We report a case of oral squamous cell carcinoma (SCC) originating in the buccal mucosa of an 18-year-old female patient with chronic graft-versus-host disease (GVHD) 9 years after HLA-identical sibling bone marrow transplantation (BMT) for Fanconi anaemia (FA). The case highlights the problems of malignant change in FA and also the increased risk of second malignancy after BMT. The literature is reviewed with regard to previous cases and the possible aetiology of tumour formation. A high index of suspicion to any epithelial lesion in FA is appropriate so that early diagnosis may lead to improved prognosis.

引用

页码：410 / 414

页数：5

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