A developing picture of lymphopoiesis in bone marrow

被引：54

作者：

Hirose, J

Kouro, T

Igarashi, H

Yokota, T

Sakaguchi, N

Kincade, PW

机构：

[1] Oklahoma Med Res Fdn, Immunobiol & Canc Program, Oklahoma City, OK 73104 USA

[2] Kumamoto Univ, Sch Med, Dept Immunol, Kumamoto 860, Japan

来源：

IMMUNOLOGICAL REVIEWS | 2002年 / 189卷

关键词：

D O I：

10.1034/j.1600-065X.2002.18904.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The earliest progenitors of lymphocytes are extremely rare and typically present among very complex populations of hematopoietic cells. Additionally, it is difficult to know how cells with any given set of characteristics are developmentally related to stem cells and maturing lymphoid precursors. However, it is now possible to divide bone marrow into progressively smaller fractions and exploit well-defined culture systems to determine which ones contain cells that can turn into lymphocytes. Analysis of steroid hormone sensitive cells and use of two-step cultures is providing additional information about the most likely differentiation pathways for B and natural killer cell lineage lymphocytes. A newly identified category of early lymphoid progenitors can now be sorted to high purity from RAG1/GFP knock in mice. Furthermore, the same experimental model makes it possible to image lymphoid progenitors in fetal and adult hematopoietic tissues.

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页码：28 / 40

页数：13

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