Developing mouse models of aging: a consideration of strain differences in age-related behavioral and neural parameters

被引:57
作者
Ingram, DK
Jucker, M
机构
[1] NIA, Ctr Gerontol Res, Lab Cellular & Mol Biol, Mol Physiol & Genet Sect,NIH, Baltimore, MD 21224 USA
[2] Univ Basel, Dept Neuropathol, Inst Pathol, CH-4003 Basel, Switzerland
关键词
genetics; recombinant inbred strains; quantitative trait loci; learning; memory; motor performance; stereology; hippocampus; neurons; glia; synapse; aping; mouse;
D O I
10.1016/S0197-4580(99)00033-0
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
Increased interest is emerging for using mouse models to assess the genetics of brain aging and age-related neurodegenerative diseases. Despite this demand, relatively little information is available on aging in behavioral or neuromorphological parameters in various mouse strains that are being used to create transgenic and null mutant mice. We review several issues regarding selection of appropriate strains as follows: (1) Does the behavioral parameter exhibit a significant age by strain interaction? (2) Do the strains differ in lifespan? (3) Are there potential intervening variables, such as strain specific performance strategies or disease, in the behavioral task being investigated that would confound the desired conclusions'! (4) Does the behavioral difference have an underlying neural correlate? In this context we present a conceptual model pertaining to the selection of mouse strains and behavioral parameters for genetic analyses. We also review the importance of applying stereological techniques for determining age-related structural changes in the mouse brain as well as the potential value of a database that would catalog this information. Thus, our intention is to underscore the growing importance of mouse models of brain aging and the concomitant need for additional information about mouse aging in general. (C) 1999 Elsevier Science Inc, All rights reserved.
引用
收藏
页码:137 / 145
页数:9
相关论文
共 90 条
[1]   PERIODIC ACID-SCHIFF (PAS)-POSITIVE, ANTIGRANULOCYTES STRUCTURES INCREASE IN THE BRAIN OF SENESCENCE ACCELERATED MOUSE (SAM) [J].
AKIYAMA, H ;
KAMEYAMA, M ;
AKIGUCHI, I ;
SUGIYAMA, H ;
KAWAMATA, T ;
FUKUYAMA, H ;
KIMURA, H ;
MATSUSHITA, M ;
TAKEDA, T .
ACTA NEUROPATHOLOGICA, 1986, 72 (02) :124-129
[2]   RADIAL MAZE PERFORMANCE AND OPEN-FIELD BEHAVIORS IN AGED C57BL/6 MICE - FURTHER EVIDENCE FOR PRESERVED COGNITIVE-ABILITIES DURING SENESCENCE [J].
AMMASSARITEULE, M ;
FAGIOLI, S ;
ROSSIARNAUD, C .
PHYSIOLOGY & BEHAVIOR, 1994, 55 (02) :341-345
[4]  
BAILEY DW, 1981, HIST GENETICS WILD M, P223
[5]   Age-related morphological changes in the hippocampus in two mouse strains [J].
Barkats, M ;
Bertholet, JY ;
CohenSalmon, C .
MECHANISMS OF AGEING AND DEVELOPMENT, 1996, 87 (03) :155-164
[6]   Transgenic models of Huntington's disease [J].
Bates, GP ;
Mangiarini, L ;
Mahal, A ;
Davies, SW .
HUMAN MOLECULAR GENETICS, 1997, 6 (10) :1633-1637
[7]   Caloric restriction and spatial learning in old mice [J].
Bellush, LL ;
Wright, AM ;
Walker, JP ;
Kopchick, J ;
Colvin, RA .
PHYSIOLOGY & BEHAVIOR, 1996, 60 (02) :541-547
[8]   RADIAL MAZE PERFORMANCE IN YOUNG AND AGED MICE - NEUROCHEMICAL CORRELATES [J].
BERNSTEIN, D ;
OLTON, DS ;
INGRAM, DK ;
WALLER, SB ;
REYNOLDS, MA ;
LONDON, ED .
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1985, 22 (02) :301-307
[9]   Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins [J].
Borchelt, DR ;
Ratovitski, T ;
vanLare, J ;
Lee, MK ;
Gonzales, V ;
Jenkins, NA ;
Copeland, NG ;
Price, DL ;
Sisodia, SS .
NEURON, 1997, 19 (04) :939-945
[10]   ALS-linked SOD1 mutant G85R mediates damage to astrocytes and promotes rapidly progressive disease with SOD1-containing inclusions [J].
Bruijn, LI ;
Becher, MW ;
Lee, MK ;
Anderson, KL ;
Jenkins, NA ;
Copeland, NG ;
Sisodia, SS ;
Rothstein, JD ;
Borchelt, DR ;
Price, DL ;
Cleveland, DW .
NEURON, 1997, 18 (02) :327-338