The impact of COPD on health status: findings from the BOLD study

被引：93

作者：

Janson, Christer ^{[1
]}

Marks, Guy ^{[2
,3
]}

Buist, Sonia ^{[5
]}

Gnatiuc, Louisa ^{[7
]}

Gislason, Thorarinn ^{[8
,9
]}

McBurnie, Mary Ann ^{[6
]}

Nielsen, Rune ^{[10
]}

Studnicka, Michael ^{[11
]}

Toelle, Brett ^{[4
]}

Benediktsdottir, Bryndis ^{[8
,9
]}

Burney, Peter ^{[7
]}

机构：

[1] Uppsala Univ, Dept Med Sci Resp Med & Allergol, S-75105 Uppsala, Sweden

[2] Liverpool Hosp, Dept Resp Med, Sydney, NSW, Australia

[3] Woolcock Inst Med Res, Sydney, NSW, Australia

[4] Woolcock Inst Med Res, Resp & Environm Epidemiol Grp, Sydney, NSW, Australia

[5] Oregon Hlth & Sci Univ, Portland, OR 97201 USA

[6] Kaiser Permanente Ctr Hlth Res, Portland, OR USA

[7] Univ London Imperial Coll Sci Technol & Med, London, England

[8] Univ Iceland, Fac Med, Reykjavik, Iceland

[9] Landspitali Univ Hosp, Reykjavik, Iceland

[10] Haukeland Hosp, Dept Thorac Med, N-5021 Bergen, Norway

[11] Paracelsus Med Univ, Dept Resp Med, Salzburg, Austria

来源：

EUROPEAN RESPIRATORY JOURNAL | 2013年 / 42卷 / 06期

基金：

英国惠康基金;

关键词：

QUALITY-OF-LIFE; RESPIRATORY SYMPTOMS; PRIMARY-CARE; RISK-FACTORS; POPULATION; DISEASE; PREVALENCE; VALIDATION; MORTALITY; HOSPITALIZATION;

D O I：

10.1183/09031936.00153712

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

100201 [内科学];

摘要：

The aim of this study was to describe the impact of chronic obstructive pulmonary disease (COPD) on health status in the Burden of Obstructive Lung Disease (BOLD) populations. We conducted a cross-sectional, general population-based survey in 11 985 subjects from 17 countries. We measured spirometric lung function and assessed health status using the Short Form 12 questionnaire. The physical and mental health component scores were calculated. Subjects with COPD (post-bronchodilator forced expiratory volume in 1 s/forced vital capacity <0.70, n=2269) had lower physical component scores (44 +/- 10 versus 48 +/- 10 units, p<0.0001) and mental health component scores (51 +/- 10 versus 52 +/- 10 units, p=0.005) than subjects without COPD. The effect of reported heart disease, hypertension and diabetes on physical health component scores (-3 to -4 units) was considerably less than the effect of COPD Global Initiative for Chronic Obstructive Lung Disease grade 3 (-8 units) or 4 (-11 units). Dyspnoea was the most important determinant of a low physical and mental health component scores. In addition, lower forced expiratory volume in 1 s, chronic cough, chronic phlegm and the presence of comorbidities were all associated with a lower physical health component score. COPD is associated with poorer health status but the effect is stronger on the physical than the mental aspects of health status. Severe COPD has a greater negative impact on health status than self-reported cardiovascular disease and diabetes.

引用

页码：1472 / 1483

页数：12

共 50 条

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Mortality after hospitalization for COPD [J].