Reproductive experience increases striatal and hypothalamic dopamine levels in pregnant rats

被引：67

作者：

Felicio, LF ^{[1
]}

Florio, JC ^{[1
]}

Sider, LH ^{[1
]}

CruzCasallas, PE ^{[1
]}

Bridges, RS ^{[1
]}

机构：

[1] TUFTS UNIV,SCH VET MED,DEPT COMPARAT MED,N GRAFTON,MA 01536

来源：

BRAIN RESEARCH BULLETIN | 1996年 / 40卷 / 04期

关键词：

parity; dopamine; prolactin; striatum; hypothalamus;

D O I：

10.1016/0361-9230(96)00008-1

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effects of parity on the dopaminergic function of rats were studied. Striatal and hypothalamic levels of dopamine (DA), 3,4-dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA), norepinephrine (NE), serotonin (5-HT), and 5-hydroxyindoleacetic acid (B-HIAA) as well as serum prolactin (PRL) levels of 7-days primigravid and multigravid rats were compared, Brains and trunk blood were collected from 1200-1400 h on day 7 of pregnancy and assayed for monoamines and their metabolites, and prolactin, respectively, Multigravid rats showed a significant increase in striatal and hypothalamic dopamine levels. A tendency to increase in striatal DOPAC levels was also observed in multigravid rats. Levels of other neurotransmitters and metabolites were not statistically different. Haloperidol (1 mg/kg) treatment induced a significant increase in multigravid 5-HT striatal levels. There was no statistical difference among primigravid and multigravid serum PRL levels after either saline or haloperidol treatment. These data suggest that prior parity produces a shift in dopaminergic activity in multigravid rats.

引用

页码：253 / 256

页数：4

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